BACKGROUND: Associations between multidrug resistance and the Mycobacterium tuberculosis Beijing genotype have been described mainly in populations with poor tuberculosis (TB) control such as prisons and inner cities, and may reflect shared risk factors rather than a biological association. OBJECTIVE: To study the association between genotype and drug resistance among TB patients in a population with adequate TB control. SETTING: Three rural districts in Vietnam. The study was performed at the Pham Ngoc Thach Tuberculosis and Lung Disease Hospital, Ho Chi Minh City, and the Tien Giang Provincial Tuberculosis and Lung Disease Hospital, My Tho, Vietnam. METHODS: Pretreatment sputum specimens were collected for culture, drug susceptibility testing and spoligotyping of all sputum smear-positive pulmonary TB patients consecutively diagnosed over a 3-year period. RESULTS: Beijing genotype infections were observed in 614 of 1744 (35%) patients. Beijing strains were more common among female (adjusted odds ratio [aOR] 1.4, P = 0.005), young (aOR 2.8, P < 0.001) and previously treated patients (aOR 2.4, P < 0.001). The Beijing genotype was associated with any resistance (aOR 3.7, P < 0.001) and multidrug resistance (aOR 6.8, P < 0.001) among new patients, and with any resistance (aOR 2.7, P = 0.005) but not with multidrug resistance (aOR 1.4, P = 0.545) among previously treated patients. CONCLUSION: In Vietnam, Beijing genotype is associated with young age and in new patients with multidrug resistance despite adequate TB control, suggesting a biological association. This potentially undermines the effectiveness of TB control in countries where Beijing genotype infections are common.
BACKGROUND: Associations between multidrug resistance and the Mycobacterium tuberculosis Beijing genotype have been described mainly in populations with poor tuberculosis (TB) control such as prisons and inner cities, and may reflect shared risk factors rather than a biological association. OBJECTIVE: To study the association between genotype and drug resistance among TB patients in a population with adequate TB control. SETTING: Three rural districts in Vietnam. The study was performed at the Pham Ngoc Thach Tuberculosis and Lung Disease Hospital, Ho Chi Minh City, and the Tien Giang Provincial Tuberculosis and Lung Disease Hospital, My Tho, Vietnam. METHODS: Pretreatment sputum specimens were collected for culture, drug susceptibility testing and spoligotyping of all sputum smear-positive pulmonary TB patients consecutively diagnosed over a 3-year period. RESULTS: Beijing genotype infections were observed in 614 of 1744 (35%) patients. Beijing strains were more common among female (adjusted odds ratio [aOR] 1.4, P = 0.005), young (aOR 2.8, P < 0.001) and previously treated patients (aOR 2.4, P < 0.001). The Beijing genotype was associated with any resistance (aOR 3.7, P < 0.001) and multidrug resistance (aOR 6.8, P < 0.001) among new patients, and with any resistance (aOR 2.7, P = 0.005) but not with multidrug resistance (aOR 1.4, P = 0.545) among previously treated patients. CONCLUSION: In Vietnam, Beijing genotype is associated with young age and in new patients with multidrug resistance despite adequate TB control, suggesting a biological association. This potentially undermines the effectiveness of TB control in countries where Beijing genotype infections are common.
Authors: Mai N T Huyen; Kristin Kremer; Nguyen T N Lan; Frank G J Cobelens; Tran N Buu; Nguyen H Dung; Maxine Caws; Edine W Tiemersma; Dick van Soolingen Journal: J Clin Microbiol Date: 2012-02-29 Impact factor: 5.948
Authors: Jurriaan E M de Steenwinkel; Marian T ten Kate; Gerjo J de Knegt; Henri A Verbrugh; Rob E Aarnoutse; Martin J Boeree; Michael A den Bakker; Dick van Soolingen; Irma A J M Bakker-Woudenberg Journal: Antimicrob Agents Chemother Date: 2012-07-16 Impact factor: 5.191
Authors: Jeroen de Keijzer; Petra E de Haas; Arnoud H de Ru; Peter A van Veelen; Dick van Soolingen Journal: Mol Cell Proteomics Date: 2014-07-14 Impact factor: 5.911
Authors: Simone C M Ribeiro; Lia Lima Gomes; Eduardo P Amaral; Marcelle R M Andrade; Fabricio M Almeida; Andreza L Rezende; Verônica R Lanes; Eulógio C Q Carvalho; Philip N Suffys; Igor Mokrousov; Elena B Lasunskaia Journal: J Clin Microbiol Date: 2014-05-14 Impact factor: 5.948
Authors: Hanna Nebenzahl-Guimaraes; Lilly M Verhagen; Martien W Borgdorff; Dick van Soolingen Journal: J Clin Microbiol Date: 2015-07-29 Impact factor: 5.948
Authors: Mai N T Huyen; Frank G J Cobelens; Tran N Buu; Nguyen T N Lan; Nguyen H Dung; Kristin Kremer; Edine W Tiemersma; Dick van Soolingen Journal: Antimicrob Agents Chemother Date: 2013-05-20 Impact factor: 5.191
Authors: Tran N Buu; Mai N T Huyen; Nguyen N T Lan; Hoang T Quy; Nguyen V Hen; Matteo Zignol; Martien W Borgdorff; Dick van Soolingen; Frank G J Cobelens Journal: Emerg Infect Dis Date: 2009-10 Impact factor: 6.883