Kunn Hadinoto1, Wean Sin Cheow. 1. School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore. kunnong@ntu.edu.sg
Abstract
OBJECTIVE: The objective of this work is to manufacture hollow spherical nanoparticulate aggregates for use as an ultrasound contrast agent by means of spray drying of nanoparticulate suspension at a fast drying rate. METHODOLOGY: Biocompatible PMMA-MeOPEGMA and silica nanoparticles are used as the model nanoparticles. The impacts of changing the nanoparticle concentration, pH, and spray drying operating condition on the size and shell thickness-to-particle radius (S/R) ratio, which governs the shell mechanical stability, are investigated. RESULTS AND CONCLUSION: The results indicate that the hollow microspheres size varies between 2 and 10 mum having S/R ratio between 2% and 4%, where the smaller size particles exhibit a higher S/R ratio. The resultant S/R ratio is found to be more influenced by process parameters acting at the nanoparticle scale (e.g., suspension pH) than by the spray drying operating condition.
OBJECTIVE: The objective of this work is to manufacture hollow spherical nanoparticulate aggregates for use as an ultrasound contrast agent by means of spray drying of nanoparticulate suspension at a fast drying rate. METHODOLOGY: Biocompatible PMMA-MeOPEGMA and silica nanoparticles are used as the model nanoparticles. The impacts of changing the nanoparticle concentration, pH, and spray drying operating condition on the size and shell thickness-to-particle radius (S/R) ratio, which governs the shell mechanical stability, are investigated. RESULTS AND CONCLUSION: The results indicate that the hollow microspheres size varies between 2 and 10 mum having S/R ratio between 2% and 4%, where the smaller size particles exhibit a higher S/R ratio. The resultant S/R ratio is found to be more influenced by process parameters acting at the nanoparticle scale (e.g., suspension pH) than by the spray drying operating condition.
Authors: H Paul Martinez; Yuko Kono; Sarah L Blair; Sergio Sandoval; Jessica Wang-Rodriguez; Robert F Mattrey; Andrew C Kummel; William C Trogler Journal: Medchemcomm Date: 2010-10 Impact factor: 3.597
Authors: Casey N Ta; Alexander Liberman; H Paul Martinez; Christopher V Barback; Robert F Mattrey; Sarah L Blair; William C Trogler; Andrew C Kummel; Zhe Wu Journal: J Vac Sci Technol B Nanotechnol Microelectron Date: 2012-03-23
Authors: Babak Kateb; Katherine Chiu; Keith L Black; Vicky Yamamoto; Bhavraj Khalsa; Julia Y Ljubimova; Hui Ding; Rameshwar Patil; Jose Antonio Portilla-Arias; Mike Modo; David F Moore; Keyvan Farahani; Michael S Okun; Neal Prakash; Josh Neman; Daniel Ahdoot; Warren Grundfest; Shouleh Nikzad; John D Heiss Journal: Neuroimage Date: 2010-02-10 Impact factor: 7.400