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Literature DB >> 19555084

Antiproliferative bistramides from Trididemnum cyclops from Madagascar (1).

Brian T Murphy¹, Shugeng Cao, Peggy Brodie, Jean Maharavo, Hanta Andriamanantoanina, Pierre Ravelonandro, David G I Kingston.

Abstract

Bioassay-guided fractionation of a marine extract from Trididemnum cyclops afforded the new lipopeptide 39-oxobistramide K (1) and the known bistramides A (2) and D (3). Structure elucidation of 1 was carried out by analysis of one- and two-dimensional NMR spectroscopy and HRMS data. Bistramides have been reported to exhibit antiproliferative activity in the nanomolar range against a number of tumor cell lines in vitro and in vivo. The isolate 1 was tested for antiproliferative activity against the A2780 cell line and exhibited an IC(50) value of 0.34 microM.

Entities: CellLine Chemical Disease Mutation Species

Mesh：

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Year: 2009 PMID： 19555084 PMCID： PMC2905825 DOI： 10.1021/np900072k

Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050

11 in total

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6. Bistramides A, B, C, D, and K: a new class of bioactive cyclic polyethers from Lissoclinum bistratum.

Authors: J F Biard; C Roussakis; J M Kornprobst; D Gouiffes-Barbin; J F Verbist; P Cotelle; M P Foster; C M Ireland; C Debitus
Journal: J Nat Prod Date: 1994-10 Impact factor: 4.050

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