Literature DB >> 19554264

Fragment-based drug discovery.

Wendy A Warr1.   

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Year:  2009        PMID： 19554264     DOI： 10.1007/s10822-009-9292-1

Source DB:  PubMed          Journal:  J Comput Aided Mol Des        ISSN： 0920-654X            Impact factor:   3.686


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  16 in total

1.  A 'rule of three' for fragment-based lead discovery?

Authors:  Miles Congreve; Robin Carr; Chris Murray; Harren Jhoti
Journal:  Drug Discov Today       Date:  2003-10-01       Impact factor: 7.851

2.  Ligand efficiency: a useful metric for lead selection.

Authors:  Andrew L Hopkins; Colin R Groom; Alexander Alex
Journal:  Drug Discov Today       Date:  2004-05-15       Impact factor: 7.851

3.  TINS, target immobilized NMR screening: an efficient and sensitive method for ligand discovery.

Authors:  Sophie Vanwetswinkel; Robert J Heetebrij; John van Duynhoven; Johan G Hollander; Dmitri V Filippov; Philip J Hajduk; Gregg Siegal
Journal:  Chem Biol       Date:  2005-02

Review 4.  A decade of fragment-based drug design: strategic advances and lessons learned.

Authors:  Philip J Hajduk; Jonathan Greer
Journal:  Nat Rev Drug Discov       Date:  2007-02-09       Impact factor: 84.694

Review 5.  The influence of drug-like concepts on decision-making in medicinal chemistry.

Authors:  Paul D Leeson; Brian Springthorpe
Journal:  Nat Rev Drug Discov       Date:  2007-11       Impact factor: 84.694

Review 6.  Informatics and modeling challenges in fragment-based drug discovery.

Authors:  Roderick E Hubbard; Ijen Chen; Ben Davis
Journal:  Curr Opin Drug Discov Devel       Date:  2007-05

7.  Discovering high-affinity ligands for proteins: SAR by NMR.

Authors:  S B Shuker; P J Hajduk; R P Meadows; S W Fesik
Journal:  Science       Date:  1996-11-29       Impact factor: 47.728

8.  Discovery of a potent inhibitor of the antiapoptotic protein Bcl-xL from NMR and parallel synthesis.

Authors:  Andrew M Petros; Jurgen Dinges; David J Augeri; Steven A Baumeister; David A Betebenner; Mark G Bures; Steven W Elmore; Philip J Hajduk; Mary K Joseph; Shelley K Landis; David G Nettesheim; Saul H Rosenberg; Wang Shen; Sheela Thomas; Xilu Wang; Irini Zanze; Haichao Zhang; Stephen W Fesik
Journal:  J Med Chem       Date:  2006-01-26       Impact factor: 7.446

9.  Design and synthesis of potent and highly selective thrombin inhibitors.

Authors:  K Hilpert; J Ackermann; D W Banner; A Gast; K Gubernator; P Hadváry; L Labler; K Müller; G Schmid; T B Tschopp
Journal:  J Med Chem       Date:  1994-11-11       Impact factor: 7.446

10.  Differences between high- and low-affinity complexes of enzymes and nonenzymes.

Authors:  Heather A Carlson; Richard D Smith; Nickolay A Khazanov; Paul D Kirchhoff; James B Dunbar; Mark L Benson
Journal:  J Med Chem       Date:  2008-10-01       Impact factor: 7.446
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  9 in total

1.  Hit clustering can improve virtual fragment screening: CDK2 and PARP1 case studies.

Authors:  Alexey A Zeifman; Victor S Stroylov; Fedor N Novikov; Oleg V Stroganov; Alexandra L Zakharenko; Svetlana N Khodyreva; Olga I Lavrik; Ghermes G Chilov
Journal:  J Mol Model       Date:  2011-11-09       Impact factor: 1.810

2.  Identifying ligand-binding hot spots in proteins using brominated fragments.

Authors:  Morten K Grøftehauge; Martin Ø Therkelsen; Rolf Taaning; Troels Skrydstrup; J Preben Morth; Poul Nissen
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2013-08-19

3.  Fragment-based drug discovery: what really works. An interview with Sandy Farmer of Boehringer Ingelheim.

Authors:  Sandy Farmer
Journal:  J Comput Aided Mol Des       Date:  2011-07-16       Impact factor: 3.686

4.  New Frontiers in Druggability.

Authors:  Dima Kozakov; David R Hall; Raeanne L Napoleon; Christine Yueh; Adrian Whitty; Sandor Vajda
Journal:  J Med Chem       Date:  2015-08-11       Impact factor: 7.446

5.  Low potency toxins reveal dense interaction networks in metabolism.

Authors:  William Bains
Journal:  BMC Syst Biol       Date:  2016-02-20

6.  Baicalin positively regulates osteoclast function by activating MAPK/Mitf signalling.

Authors:  Li Lu; Li Rao; Huanhuan Jia; Jun Chen; Xingyan Lu; Guozhu Yang; Qingnan Li; Kenneth Ka Ho Lee; Li Yang
Journal:  J Cell Mol Med       Date:  2017-02-03       Impact factor: 5.310

7.  Comparative amino acid decomposition analysis of potent type I p38α inhibitors.

Authors:  Ahmad Ebadi; Nima Razzaghi-Asl; Mehdi Khoshneviszadeh; Ramin Miri
Journal:  Daru       Date:  2013-05-29       Impact factor: 3.117

8.  Theoretical prediction of hydrogen-bond basicity pKBHX using quantum chemical topology descriptors.

Authors:  Anthony J Green; Paul L A Popelier
Journal:  J Chem Inf Model       Date:  2014-02-04       Impact factor: 4.956

9.  Exhaustive sampling of the fragment space associated to a molecule leading to the generation of conserved fragments.

Authors:  Kathrin Heikamp; Fabio Zuccotto; Michael Kiczun; Peter Ray; Ian H Gilbert
Journal:  Chem Biol Drug Des       Date:  2017-12-12       Impact factor: 2.817
  9 in total

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