Literature DB >> 19553113

Dopamine D(3) receptor antagonists: The quest for a potentially selective PET ligand. Part two: Lead optimization.

Fabrizio Micheli1, Ian Holmes, Luca Arista, Giorgio Bonanomi, Simone Braggio, Francesca Cardullo, Romano Di Fabio, Daniele Donati, Gabriella Gentile, Dieter Hamprecht, Silvia Terreni, Christian Heidbreder, Chiara Savoia, Cristiana Griffante, Angela Worby.   

Abstract

The lead optimization process to identify new selective dopamine D(3) receptor antagonists is reported. DMPK parameters and binding data suggest that selective D(3) receptor antagonists as potential PET ligands might have been identified.

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Year:  2009        PMID： 19553113     DOI： 10.1016/j.bmcl.2009.06.028

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Synthesis and pre-clinical evaluation of a potential radiotracer for PET imaging of the dopamine D3 receptor.

Authors:  Megan N Stewart; Xia Shao; Timothy J Desmond; Taylor J Forrest; Janna Arteaga; Jenelle Stauff; Peter J H Scott
Journal:  Medchemcomm       Date:  2018-06-29       Impact factor: 3.597

2.  Data-Driven Analysis of Fluorination of Ligands of Aminergic G Protein Coupled Receptors.

Authors:  Wojciech Pietruś; Rafał Kurczab; Dagmar Stumpfe; Andrzej J Bojarski; Jürgen Bajorath
Journal:  Biomolecules       Date:  2021-11-08
  2 in total

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