| Literature DB >> 19553109 |
Marcelo Calderón1, Ralph Graeser, Felix Kratz, Rainer Haag.
Abstract
In this Letter we report the synthesis and in vitro studies of cleavable polymer-drug conjugates derived from dendritic polyglycerol and maleimide-bearing prodrugs of doxorubicin and methotrexate that are cleaved by cathepsin B. Cleavage properties and cytotoxicity of the new conjugates are presented.Entities:
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Year: 2009 PMID： 19553109 DOI： 10.1016/j.bmcl.2009.05.058
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823