BACKGROUND: The authors implemented a controlled, randomized trial that compared 2 interventions: the provision of written resource navigation information (enhanced usual care [EUC]) versus written information plus patient navigation (TPN) aimed at improving adjuvant treatment adherence and follow-up among 487 low-income, predominantly Hispanic women with breast cancer or gynecologic cancer. METHODS: Women were randomized to receive either TPN or EUC; and chemotherapy, radiation therapy, hormone therapy, and follow-up were assessed over 12 months. Patients with breast cancer were analyzed separately from patients with gynecologic cancer. RESULTS:Overall adherence rates ranged from 87% to 94%, and there were no significant differences between the TPN group and the EUC group. Among women with breast cancer, 90% of the EUC group and 88% of the TPN group completed chemotherapy (14% of the EUC group and 26% of the TPN group delayed the completion of chemotherapy), 2% of the EUC group and 4% of the TPN group failed to complete chemotherapy, and 8% of the EUC group and 7% of the TPN group refused chemotherapy. Radiation treatment adherence was similar between the groups: Ninety percent of patients completed radiation (40% of the EUC group and 42% of the TPN group delayed the completion of radiation); in both groups, 2% failed to complete radiation, and 8% refused radiation. Among gynecologic patients, 87% of the EUC group and 94% of the TPN group completed chemotherapy (41% of the EUC group and 31% of the TPN group completed it with delays), 7% of the EUC group and 6% of the TPN group failed to complete chemotherapy, 6% of the EUC refused chemotherapy, 87% of the EUC group and 84% of the TPN group completed radiation (51% of the EUC group and 42% of the TPN with delays), 5% of the EUC group and 8% of the TPN group failed to complete radiation, and 8% of the EUC group and 5% of the TPN group refused radiation. CONCLUSIONS: Treatment adherence across randomized groups was notably higher than reported in previous studies, suggesting that active telephone patient navigation or written resource informational materials may facilitate adherence among low-income, predominantly Hispanic women. Adherence also may have be facilitated by federal-state breast and cervical cancer treatment funding. 2009 American Cancer Society.
RCT Entities:
BACKGROUND: The authors implemented a controlled, randomized trial that compared 2 interventions: the provision of written resource navigation information (enhanced usual care [EUC]) versus written information plus patient navigation (TPN) aimed at improving adjuvant treatment adherence and follow-up among 487 low-income, predominantly Hispanic women with breast cancer or gynecologic cancer. METHODS:Women were randomized to receive either TPN or EUC; and chemotherapy, radiation therapy, hormone therapy, and follow-up were assessed over 12 months. Patients with breast cancer were analyzed separately from patients with gynecologic cancer. RESULTS: Overall adherence rates ranged from 87% to 94%, and there were no significant differences between the TPN group and the EUC group. Among women with breast cancer, 90% of the EUC group and 88% of the TPN group completed chemotherapy (14% of the EUC group and 26% of the TPN group delayed the completion of chemotherapy), 2% of the EUC group and 4% of the TPN group failed to complete chemotherapy, and 8% of the EUC group and 7% of the TPN group refused chemotherapy. Radiation treatment adherence was similar between the groups: Ninety percent of patients completed radiation (40% of the EUC group and 42% of the TPN group delayed the completion of radiation); in both groups, 2% failed to complete radiation, and 8% refused radiation. Among gynecologic patients, 87% of the EUC group and 94% of the TPN group completed chemotherapy (41% of the EUC group and 31% of the TPN group completed it with delays), 7% of the EUC group and 6% of the TPN group failed to complete chemotherapy, 6% of the EUC refused chemotherapy, 87% of the EUC group and 84% of the TPN group completed radiation (51% of the EUC group and 42% of the TPN with delays), 5% of the EUC group and 8% of the TPN group failed to complete radiation, and 8% of the EUC group and 5% of the TPN group refused radiation. CONCLUSIONS: Treatment adherence across randomized groups was notably higher than reported in previous studies, suggesting that active telephone patient navigation or written resource informational materials may facilitate adherence among low-income, predominantly Hispanic women. Adherence also may have be facilitated by federal-state breast and cervical cancer treatment funding. 2009 American Cancer Society.
Authors: K O Anderson; T R Mendoza; V Valero; S P Richman; C Russell; J Hurley; C DeLeon; P Washington; G Palos; R Payne; C S Cleeland Journal: Cancer Date: 2000-04-15 Impact factor: 6.860
Authors: Tomasz P Srokowski; Shenying Fang; Zhigang Duan; Thomas A Buchholz; Gabriel N Hortobagyi; James S Goodwin; Sharon H Giordano Journal: Cancer Date: 2008-07-01 Impact factor: 6.860
Authors: Martin P Charns; Mary K Foster; Elaine C Alligood; Justin K Benzer; James F Burgess; Donna Li; Nathalie M McIntosh; Allison Burness; Melissa R Partin; Steven B Clauser Journal: J Natl Cancer Inst Monogr Date: 2012-05
Authors: Cathy D Meade; Kristen J Wells; Mariana Arevalo; Ercilia R Calcano; Marlene Rivera; Yolanda Sarmiento; Harold P Freeman; Richard G Roetzheim Journal: J Cancer Educ Date: 2014-09 Impact factor: 2.037
Authors: Horia Vulpe; Janet Ellis; Shao Hui Huang; Eshetu G Atenafu; Raymond W Jang; Gary Rodin; Jolie Ringash Journal: Support Care Cancer Date: 2016-11-04 Impact factor: 3.603
Authors: Vanessa B Sheppard; Luciane R Cavalli; Chiranjeev Dash; Yasmine M Kanaan; Asma A Dilawari; Sara Horton; Kepher H Makambi Journal: Clin Breast Cancer Date: 2017-01-06 Impact factor: 3.225
Authors: Carlos H Barcenas; Ning Zhang; Hui Zhao; Zhigang Duan; Thomas A Buchholz; Gabriel N Hortobagyi; Sharon H Giordano Journal: Oncologist Date: 2012-02-27
Authors: Kristen J Wells; Cathy D Meade; Ercilia Calcano; Ji-Hyun Lee; Desiree Rivers; Richard G Roetzheim Journal: J Cancer Educ Date: 2011-12 Impact factor: 2.037
Authors: Karen M Freund; Tracy A Battaglia; Elizabeth Calhoun; Julie S Darnell; Donald J Dudley; Kevin Fiscella; Martha L Hare; Nancy LaVerda; Ji-Hyun Lee; Paul Levine; David M Murray; Steven R Patierno; Peter C Raich; Richard G Roetzheim; Melissa Simon; Frederick R Snyder; Victoria Warren-Mears; Elizabeth M Whitley; Paul Winters; Gregory S Young; Electra D Paskett Journal: J Natl Cancer Inst Date: 2014-06-17 Impact factor: 13.506