Literature DB >> 19551466

Role of the metabotropic glutamate receptor subtype 1 in the harmaline-induced tremor in rats.

Wacław Kolasiewicz1, Katarzyna Kuter, Jadwiga Wardas, Krystyna Ossowska.   

Abstract

The present study shows that JNJ 16259685-a selective antagonist of glutamate metabotropic receptor subtype 1 (mGluR1) injected in doses of 0.16 and 0.32 mg/kg sc strongly enhances tremor of forelimbs, head and trunk, hypolocomotion, and ataxia induced by harmaline (7.5 mg/kg ip) in rats. JNJ 16259685 inhibited locomotor and exploratory activity per se. These results may suggest an inhibitory influence of mGluR1 on the harmaline-induced motor disturbances.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19551466     DOI： 10.1007/s00702-009-0254-5

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  29 in total

1.  Climbing fiber activation of metabotropic glutamate receptors on cerebellar purkinje neurons.

Authors:  Jeffrey A Dzubay; Thomas S Otis
Journal:  Neuron       Date:  2002-12-19       Impact factor: 17.173

2.  Excitation of cerebellar interneurons by group I metabotropic glutamate receptors.

Authors:  Movses H Karakossian; Thomas S Otis
Journal:  J Neurophysiol       Date:  2004-05-19       Impact factor: 2.714

3.  Imaging parallel fiber and climbing fiber responses and their short-term interactions in the mouse cerebellar cortex in vivo.

Authors:  R L Dunbar; G Chen; W Gao; K C Reinert; R Feddersen; T J Ebner
Journal:  Neuroscience       Date:  2004       Impact factor: 3.590

4.  Alcohol potently modulates climbing fiber-->Purkinje neuron synapses: role of metabotropic glutamate receptors.

Authors:  Mario Carta; Manuel Mameli; C Fernando Valenzuela
Journal:  J Neurosci       Date:  2006-02-15       Impact factor: 6.167

5.  Climbing fiber-triggered metabotropic slow potentials enhance dendritic calcium transients and simple spike firing in cerebellar Purkinje cells.

Authors:  Qi Yuan; De-Lai Qiu; John T Weber; Christian Hansel; Thomas Knöpfel
Journal:  Mol Cell Neurosci       Date:  2007-05-24       Impact factor: 4.314

6.  Postsynaptic current mediated by metabotropic glutamate receptors in cerebellar Purkinje cells.

Authors:  F Tempia; M C Miniaci; D Anchisi; P Strata
Journal:  J Neurophysiol       Date:  1998-08       Impact factor: 2.714

7.  mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination.

Authors:  T Ichise; M Kano; K Hashimoto; D Yanagihara; K Nakao; R Shigemoto; M Katsuki; A Aiba
Journal:  Science       Date:  2000-06-09       Impact factor: 47.728

8.  The striatum as a target for anti-rigor effects of an antagonist of mGluR1, but not an agonist of group II metabotropic glutamate receptors.

Authors:  Krystyna Ossowska; Jolanta Konieczny; Andrzej Pilc; Stanislaw Wolfarth
Journal:  Brain Res       Date:  2002-09-20       Impact factor: 3.252

9.  Harmaline induced tremor. III. A combined simple units, horseradish peroxidase, and 2-deoxyglucose study of the olivocerebellar system in the rat.

Authors:  J F Bernard; C Buisseret-Delmas; C Compoint; S Laplante
Journal:  Exp Brain Res       Date:  1984       Impact factor: 1.972

Review 10.  Rodent models of tremor.

Authors:  Hideto Miwa
Journal:  Cerebellum       Date:  2007       Impact factor: 3.648
View more
  8 in total

Review 1.  Therapeutic strategies in fragile X syndrome: dysregulated mGluR signaling and beyond.

Authors:  Christina Gross; Elizabeth M Berry-Kravis; Gary J Bassell
Journal:  Neuropsychopharmacology       Date:  2011-07-27       Impact factor: 7.853

2.  Cannabinoid type 1 receptor antagonism ameliorates harmaline-induced essential tremor in rat.

Authors:  Hassan Abbassian; Benjamin J Whalley; Vahid Sheibani; Mohammad Shabani
Journal:  Br J Pharmacol       Date:  2016-10-04       Impact factor: 8.739

Review 3.  Linking Essential Tremor to the Cerebellum-Animal Model Evidence.

Authors:  Adrian Handforth
Journal:  Cerebellum       Date:  2016-06       Impact factor: 3.847

4.  Lesion of the cerebellar noradrenergic innervation enhances the harmaline-induced tremor in rats.

Authors:  Wacław Kolasiewicz; Katarzyna Kuter; Przemysław Nowak; Agnieszka Pastuszka; Krystyna Ossowska
Journal:  Cerebellum       Date:  2011-06       Impact factor: 3.847

5.  Targeted treatments for fragile X syndrome.

Authors:  Elizabeth Berry-Kravis; Andrew Knox; Crystal Hervey
Journal:  J Neurodev Disord       Date:  2011-02-19       Impact factor: 4.025

6.  Riluzole Ameliorates Harmaline-induced Tremor in Rat.

Authors:  Fatemeh Rahimi Shourmasti; Iran Goudarzi; Kataneh Abrari; Mahmoud Elahdadi Salmani; Taghi Laskarbolouki
Journal:  Basic Clin Neurosci       Date:  2014

Review 7.  Neurotoxic Agent-Induced Injury in Neurodegenerative Disease Model: Focus on Involvement of Glutamate Receptors.

Authors:  Md Jakaria; Shin-Young Park; Md Ezazul Haque; Govindarajan Karthivashan; In-Su Kim; Palanivel Ganesan; Dong-Kug Choi
Journal:  Front Mol Neurosci       Date:  2018-08-29       Impact factor: 5.639

8.  Harmaline tremor: underlying mechanisms in a potential animal model of essential tremor.

Authors:  Adrian Handforth
Journal:  Tremor Other Hyperkinet Mov (N Y)       Date:  2012-09-12
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.