BACKGROUND: Infections caused by Candida are an emerging pathology on surgical wards. The aim of the present study was to evaluate the incidence, characteristics, and predictive factors of mortality in patients colonized and/or infected by Candida spp. in this setting. METHODS: A consecutive series of 105 patients hospitalized on a general surgery ward between 2000 and 2004 were included, and 118 positive cultures for Candida were identified. The variables age, sex, previous medical history, current disease, anemia, ICU stay, type and localization of the microorganism, need for parenteral nutrition, and transfusions were recorded. The primary outcome was in-hospital mortality. A univariate analysis was performed to determine which of these variables were associated with mortality. With a logistic regression model, independent prognostic factors of mortality were determined. RESULTS: The prevalence of patients colonized and/or infected by Candida on our surgical ward was 0.98% (CI 95%: 0.79-1.17), and the incidence was 49 cases per 1,000 patient-years. Of the 105 patients in this series, 56 were men (53%) and 49 women (47%); the mean age was 63.8 years (SD +/- 15.7). Twelve patients (11.4%) had candidemia. Crude mortality was 23% (24 patients), whereas the mortality attributable to candidemia was 25% (3/12 cases). Anemia (p = 0.001); transfusions (p = 0.003), and an ICU stay (p = 0.002) were associated with mortality. Candidemia was associated with neoplasms (p = 0.02) and the infection caused by Candida parapsilosis (p = 0.04). The only independent factor related to mortality was the anemia (p = 0.028; Odds Ratio: 6.43; 95% CI: 1.23-33.73). CONCLUSIONS: Colonization and/or infection by Candida spp. in non-ICU hospitalized surgical patients implies a relative high mortality. Anemia is an independent factor for mortality.
BACKGROUND: Infections caused by Candida are an emerging pathology on surgical wards. The aim of the present study was to evaluate the incidence, characteristics, and predictive factors of mortality in patients colonized and/or infected by Candida spp. in this setting. METHODS: A consecutive series of 105 patients hospitalized on a general surgery ward between 2000 and 2004 were included, and 118 positive cultures for Candida were identified. The variables age, sex, previous medical history, current disease, anemia, ICU stay, type and localization of the microorganism, need for parenteral nutrition, and transfusions were recorded. The primary outcome was in-hospital mortality. A univariate analysis was performed to determine which of these variables were associated with mortality. With a logistic regression model, independent prognostic factors of mortality were determined. RESULTS: The prevalence of patients colonized and/or infected by Candida on our surgical ward was 0.98% (CI 95%: 0.79-1.17), and the incidence was 49 cases per 1,000 patient-years. Of the 105 patients in this series, 56 were men (53%) and 49 women (47%); the mean age was 63.8 years (SD +/- 15.7). Twelve patients (11.4%) had candidemia. Crude mortality was 23% (24 patients), whereas the mortality attributable to candidemia was 25% (3/12 cases). Anemia (p = 0.001); transfusions (p = 0.003), and an ICU stay (p = 0.002) were associated with mortality. Candidemia was associated with neoplasms (p = 0.02) and the infection caused by Candida parapsilosis (p = 0.04). The only independent factor related to mortality was the anemia (p = 0.028; Odds Ratio: 6.43; 95% CI: 1.23-33.73). CONCLUSIONS: Colonization and/or infection by Candida spp. in non-ICU hospitalized surgical patients implies a relative high mortality. Anemia is an independent factor for mortality.
Authors: Michael G Hughes; Heather L Evans; Lynn Lightfoot; Tae W Chong; Robert L Smith; Daniel P Raymond; Shawn J Pelletier; Jeffrey A Claridge; Timothy L Pruett; Robert G Sawyer Journal: Surg Infect (Larchmt) Date: 2003 Impact factor: 2.150
Authors: P S McKinnon; D A Goff; J W Kern; J W Devlin; J F Barletta; S J Sierawski; A C Mosenthal; P Gore; A J Ambegaonkar; T J Lubowski Journal: Arch Surg Date: 2001-12
Authors: M H Nguyen; J E Peacock; A J Morris; D C Tanner; M L Nguyen; D R Snydman; M M Wagener; M G Rinaldi; V L Yu Journal: Am J Med Date: 1996-06 Impact factor: 4.965
Authors: R Luzzati; G Amalfitano; L Lazzarini; F Soldani; S Bellino; M Solbiati; M C Danzi; S Vento; G Todeschini; C Vivenza; E Concia Journal: Eur J Clin Microbiol Infect Dis Date: 2000-08 Impact factor: 3.267
Authors: Pierre Emmanuel Charles; Jean Marc Doise; Jean Pierre Quenot; Hervé Aube; Frédéric Dalle; Pascal Chavanet; Nadine Milesi; Ludwig Serge Aho; Henri Portier; Bernard Blettery Journal: Intensive Care Med Date: 2003-09-10 Impact factor: 17.440
Authors: C León; F Alvarez-Lerma; S Ruiz-Santana; M A León; J Nolla; R Jordá; P Saavedra; M Palomar Journal: Eur J Clin Microbiol Infect Dis Date: 2008-08-29 Impact factor: 3.267