Literature DB >> 1955069

PLC-alpha: a common mediator of the action of estrogen and other hormones?

C V Mobbs1, M Kaplitt, L M Kow, D W Pfaff.   

Abstract

The phosphatidyl inositol (PI) second messenger pathway may mediate diverse effects of estrogen, including its potentiation of the effects of other hormones. Both estradiol (E2) and luteinizing hormone-releasing hormone (LHRH) induce a putative isoform of PI-specific phospholipase C-alpha (PLC-alpha). PLC-alpha catalyzes PI hydrolysis, which in turn can increase protein kinase C (PKC) activation, Ca2+ mobilization, and arachidonic acid metabolism. Estrogen activates the PI pathway, and components of the PI pathway can mimic or enhance some effects of estrogen. Furthermore, estrogen potentiates effects of several hormones (e.g., LHRH, prolactin, and insulin) which can also act through the PI system. PLC-alpha may therefore provide a common second messenger pathway mediating the potentiation by E2 of the effects of other hormones; in addition it may also mediate some or all of the many actions of E2, since components of the PI pathway can have secretory, trophic, toxic, and neuromodulatory effects.

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Year:  1991        PMID： 1955069     DOI： 10.1016/0303-7207(91)90136-g

Source DB:  PubMed          Journal:  Mol Cell Endocrinol        ISSN： 0303-7207            Impact factor:   4.102


  9 in total

1.  In the ventral tegmental area, progestogens' membrane-mediated actions for lordosis of rats involve the second-messenger phospholipase C.

Authors:  Cheryl A Frye; Alicia A Walf
Journal:  Brain Res       Date:  2008-07-16       Impact factor: 3.252

2.  Estradiol activates group I and II metabotropic glutamate receptor signaling, leading to opposing influences on cAMP response element-binding protein.

Authors:  Marissa I Boulware; Jason P Weick; Bryan R Becklund; Sidney P Kuo; Rachel D Groth; Paul G Mermelstein
Journal:  J Neurosci       Date:  2005-05-18       Impact factor: 6.167

Review 3.  Importance of sex to pain and its amelioration; relevance of spinal estrogens and its membrane receptors.

Authors:  Alan R Gintzler; Nai-Jiang Liu
Journal:  Front Neuroendocrinol       Date:  2012-10-02       Impact factor: 8.606

Review 4.  Membrane estrogen receptors activate metabotropic glutamate receptors to influence nervous system physiology.

Authors:  Marissa I Boulware; Paul G Mermelstein
Journal:  Steroids       Date:  2008-11-25       Impact factor: 2.668

Review 5.  Genetic influences on glucose neurotoxicity, aging, and diabetes: a possible role for glucose hysteresis.

Authors:  C V Mobbs
Journal:  Genetica       Date:  1993       Impact factor: 1.082

Review 6.  Membrane-localised oestrogen receptor alpha and beta influence neuronal activity through activation of metabotropic glutamate receptors.

Authors:  P G Mermelstein
Journal:  J Neuroendocrinol       Date:  2009-03       Impact factor: 3.627

7.  Estrogen reduces the excitability of the female rat medial amygdala afferents from the medial preoptic area but not those from the lateral septum.

Authors:  M Yoshida; S Suga; Y Sakuma
Journal:  Exp Brain Res       Date:  1994       Impact factor: 1.972

8.  Ribozyme knockdown functionally links a 1,25(OH)2D3 membrane binding protein (1,25D3-MARRS) and phosphate uptake in intestinal cells.

Authors:  I Nemere; M C Farach-Carson; B Rohe; T M Sterling; A W Norman; B D Boyan; S E Safford
Journal:  Proc Natl Acad Sci U S A       Date:  2004-04-29       Impact factor: 11.205

Review 9.  Sex differences in opioid analgesia and addiction: interactions among opioid receptors and estrogen receptors.

Authors:  Cynthia Wei-Sheng Lee; Ing-Kang Ho
Journal:  Mol Pain       Date:  2013-09-08       Impact factor: 3.395
  9 in total

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