BACKGROUND: Hepatitis B virus (HBV) and hepatitis C virus (HCV) are the major risk factors for hepatocellular carcinoma (HCC). The association of diabetes mellitus with HCC suggests that dietary glycemic load (GL) may influence HCC risk. We have examined the association between dietary GL and HCC. PATIENTS AND METHODS: We conducted a hospital-based case-control study in Italy in 1999-2002, including 185 HCC cases and 412 controls who answered a validated food frequency questionnaire and provided blood samples. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were computed using unconditional multiple logistic regression. RESULTS: We observed a positive association between GL and HCC overall, with an OR of 3.02 (95% CI 1.49-6.12) for the highest quintile of GL compared with the lowest and a significant trend. The OR among HCC cases with evidence of chronic infection with HBV and/or HCV was 3.25 (95% CI 1.46-7.22), while the OR among those with no evidence of infection was 2.45 (95% CI 0.69-8.64), with no significant trend. The association was not explained by the presence of cirrhosis or diabetes. CONCLUSIONS: High dietary GL is associated with increased risk for HCC. The positive association was most pronounced among HCC cases with HBV and/or HCV markers.
BACKGROUND:Hepatitis B virus (HBV) and hepatitis C virus (HCV) are the major risk factors for hepatocellular carcinoma (HCC). The association of diabetes mellitus with HCC suggests that dietary glycemic load (GL) may influence HCC risk. We have examined the association between dietary GL and HCC. PATIENTS AND METHODS: We conducted a hospital-based case-control study in Italy in 1999-2002, including 185 HCC cases and 412 controls who answered a validated food frequency questionnaire and provided blood samples. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were computed using unconditional multiple logistic regression. RESULTS: We observed a positive association between GL and HCC overall, with an OR of 3.02 (95% CI 1.49-6.12) for the highest quintile of GL compared with the lowest and a significant trend. The OR among HCC cases with evidence of chronic infection with HBV and/or HCV was 3.25 (95% CI 1.46-7.22), while the OR among those with no evidence of infection was 2.45 (95% CI 0.69-8.64), with no significant trend. The association was not explained by the presence of cirrhosis or diabetes. CONCLUSIONS: High dietary GL is associated with increased risk for HCC. The positive association was most pronounced among HCC cases with HBV and/or HCV markers.
Authors: Marin E Healy; Jenny D Y Chow; Frances L Byrne; David S Breen; Norbert Leitinger; Chien Li; Carolin Lackner; Stephen H Caldwell; Kyle L Hoehn Journal: J Hepatol Date: 2014-10-23 Impact factor: 25.083
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Authors: V Fedirko; A Lukanova; C Bamia; A Trichopolou; E Trepo; U Nöthlings; S Schlesinger; K Aleksandrova; P Boffetta; A Tjønneland; N F Johnsen; K Overvad; G Fagherazzi; A Racine; M C Boutron-Ruault; V Grote; R Kaaks; H Boeing; A Naska; G Adarakis; E Valanou; D Palli; S Sieri; R Tumino; P Vineis; S Panico; H B As Bueno-de-Mesquita; P D Siersema; P H Peeters; E Weiderpass; G Skeie; D Engeset; J R Quirós; R Zamora-Ros; M J Sánchez; P Amiano; J M Huerta; A Barricarte; D Johansen; B Lindkvist; M Sund; M Werner; F Crowe; K T Khaw; P Ferrari; I Romieu; S C Chuang; E Riboli; M Jenab Journal: Ann Oncol Date: 2012-11-02 Impact factor: 32.976
Authors: Wanshui Yang; Jing Sui; Longgang Zhao; Yanan Ma; Fred K Tabung; Tracey G Simon; Dong Hoon Lee; Xufen Zeng; Long H Nguyen; Jeffrey A Meyerhardt; Andrew T Chan; Edward L Giovannucci; Xuehong Zhang Journal: Cancer Epidemiol Biomarkers Prev Date: 2021-01-29 Impact factor: 4.090