BACKGROUND: Previous studies reported an association between weak habituation of skin conductance orienting response and psychosis proneness. The aim of this study was to investigate the relationship among neuregulin 1 (NRG1)-stimulated AKT phosphorylation (a putative marker of psychosis), orienting response habituation, delusional ideas, anxiety, and depression in nonclinical individuals. METHODS: One hundred twenty individuals participated in the skin conductance measurements. Weak and strong habituators were compared on measures of NRG1-stimulated AKT phosphorylation in B lymphoblasts, delusional ideas, anxiety, and depression. The predictors of delusional ideas were determined by multiple regression analysis. RESULTS: Weak habituators displayed higher levels of delusional ideas/anxiety and a lower ratio of phosphorylated AKT as compared with strong habituators. There were 3 significant predictors of delusional ideas: decreased habituation, NRG1-induced AKT phosphorylation, and anxiety. Age, gender, education, IQ, and depression did not predict delusional ideas. CONCLUSIONS: These results suggest that decreased habituation of arousal, NRG1-induced AKT phosphorylation, and anxiety are related to delusional ideation in the general population.
BACKGROUND: Previous studies reported an association between weak habituation of skin conductance orienting response and psychosis proneness. The aim of this study was to investigate the relationship among neuregulin 1 (NRG1)-stimulated AKT phosphorylation (a putative marker of psychosis), orienting response habituation, delusional ideas, anxiety, and depression in nonclinical individuals. METHODS: One hundred twenty individuals participated in the skin conductance measurements. Weak and strong habituators were compared on measures of NRG1-stimulated AKT phosphorylation in B lymphoblasts, delusional ideas, anxiety, and depression. The predictors of delusional ideas were determined by multiple regression analysis. RESULTS: Weak habituators displayed higher levels of delusional ideas/anxiety and a lower ratio of phosphorylated AKT as compared with strong habituators. There were 3 significant predictors of delusional ideas: decreased habituation, NRG1-induced AKT phosphorylation, and anxiety. Age, gender, education, IQ, and depression did not predict delusional ideas. CONCLUSIONS: These results suggest that decreased habituation of arousal, NRG1-induced AKT phosphorylation, and anxiety are related to delusional ideation in the general population.
Authors: Ying-Jiun J Chen; Madeleine A Johnson; Michael D Lieberman; Rose E Goodchild; Scott Schobel; Nicole Lewandowski; Gorazd Rosoklija; Ruei-Che Liu; Jay A Gingrich; Scott Small; Holly Moore; Andrew J Dwork; David A Talmage; Lorna W Role Journal: J Neurosci Date: 2008-07-02 Impact factor: 6.167
Authors: Hreinn Stefansson; Engilbert Sigurdsson; Valgerdur Steinthorsdottir; Soley Bjornsdottir; Thordur Sigmundsson; Shyamali Ghosh; Jon Brynjolfsson; Steinunn Gunnarsdottir; Omar Ivarsson; Thomas T Chou; Omar Hjaltason; Birgitta Birgisdottir; Helgi Jonsson; Vala G Gudnadottir; Elsa Gudmundsdottir; Asgeir Bjornsson; Brynjolfur Ingvarsson; Andres Ingason; Sigmundur Sigfusson; Hronn Hardardottir; Richard P Harvey; Donna Lai; Mingdong Zhou; Daniela Brunner; Vincent Mutel; Acuna Gonzalo; Greg Lemke; Jesus Sainz; Gardar Johannesson; Thorkell Andresson; Daniel Gudbjartsson; Andrei Manolescu; Michael L Frigge; Mark E Gurney; Augustine Kong; Jeffrey R Gulcher; Hannes Petursson; Kari Stefansson Journal: Am J Hum Genet Date: 2002-07-23 Impact factor: 11.025
Authors: Hao-Yang Tan; Kristin K Nicodemus; Qiang Chen; Zhen Li; Jennifer K Brooke; Robyn Honea; Bhaskar S Kolachana; Richard E Straub; Andreas Meyer-Lindenberg; Yoshitasu Sei; Venkata S Mattay; Joseph H Callicott; Daniel R Weinberger Journal: J Clin Invest Date: 2008-06 Impact factor: 14.808
Authors: John M Hettema; Seon-Sook An; Jozsef Bukszar; Edwin J C G van den Oord; Michael C Neale; Kenneth S Kendler; Xiangning Chen Journal: Biol Psychiatry Date: 2008-04-23 Impact factor: 13.382
Authors: Michael A Siuta; Sabrina D Robertson; Heidi Kocalis; Christine Saunders; Paul J Gresch; Vivek Khatri; Chiyo Shiota; J Philip Kennedy; Craig W Lindsley; Lynette C Daws; Daniel B Polley; Jeremy Veenstra-Vanderweele; Gregg D Stanwood; Mark A Magnuson; Kevin D Niswender; Aurelio Galli Journal: PLoS Biol Date: 2010-06-08 Impact factor: 8.029