Literature DB >> 19547724

Unsteady propagation of a liquid plug in a liquid-lined straight tube.

Hideki Fujioka1, Shuichi Takayama, James B Grotberg.   

Abstract

This paper considers the propagation of a liquid plug driven by a constant pressure within a rigid axisymmetric tube whose inner surface is coated by a thin liquid film. The Navier-Stokes equations are solved using the finite-volume method and the SIMPLEST algorithm. The effects of precursor film thickness, initial plug length, pressure drop across the plug, and constant surface tension on the plug behavior and tube wall mechanical stresses are investigated. As a plug propagates through a liquid-lined tube, the plug gains liquid from the leading front film, and it deposits liquid into the trailing film. If the trailing film is thicker (thinner) than the precursor film, the plug volume decreases (increases) as it propagates. For a decreasing volume, eventually the plug ruptures. Under a specific set of conditions, the trailing film thickness equals the precursor film thickness, which leads to steady state results. The plug speed decreases as the precursor film thins because the resistance to the moving front meniscus increases. As the pressure drop across the plug decreases, the plug speed decreases resulting in thinning of the trailing film. As the plug length becomes longer, the viscous resistance in the plug core region increases, which slows the plug and causes the trailing film to become even thinner. The magnitude of the pressure and shear stress at the tube inner wall is maximum in the front meniscus region, and it increases with a thinner precursor film. As the surface tension increases, the plug propagation speed decreases, the strength of the wall pressure in the front meniscus region increases, and the pressure gradient around the peak pressure becomes steeper.

Year:  2008        PMID: 19547724      PMCID: PMC2698282          DOI: 10.1063/1.2938381

Source DB:  PubMed          Journal:  Phys Fluids (1994)        ISSN: 1070-6631            Impact factor:   3.521


  35 in total

1.  Mechanisms of surface-tension-induced epithelial cell damage in a model of pulmonary airway reopening.

Authors:  Anastacia M Bilek; Kay C Dee; Donald P Gaver
Journal:  J Appl Physiol (1985)       Date:  2002-10-25

2.  Architecture of the human lung. Use of quantitative methods establishes fundamental relations between size and number of lung structures.

Authors:  E R WEIBEL; D M GOMEZ
Journal:  Science       Date:  1962-08-24       Impact factor: 47.728

3.  High-frequency oscillatory ventilation with partial liquid ventilation in a model of acute respiratory failure.

Authors:  H P Baden; J D Mellema; S L Bratton; P P O'Rourke; J C Jackson
Journal:  Crit Care Med       Date:  1997-02       Impact factor: 7.598

4.  Surfactant replacement therapy for severe neonatal respiratory distress syndrome: an international randomized clinical trial. Collaborative European Multicenter Study Group.

Authors: 
Journal:  Pediatrics       Date:  1988-11       Impact factor: 7.124

5.  Liquid ventilation with perflubron in the treatment of rats with pneumococcal pneumonia.

Authors:  Eric W Dickson; Stephen O Heard; Thomas E Tarara; Jeffry G Weers; Angela B Brueggemann; Gary V Doern
Journal:  Crit Care Med       Date:  2002-02       Impact factor: 7.598

6.  Partial liquid ventilation with perflubron in premature infants with severe respiratory distress syndrome. The LiquiVent Study Group.

Authors:  C L Leach; J S Greenspan; S D Rubenstein; T H Shaffer; M R Wolfson; J C Jackson; R DeLemos; B P Fuhrman
Journal:  N Engl J Med       Date:  1996-09-12       Impact factor: 91.245

7.  The stability of peripheral airways.

Authors:  P T Macklem; D F Proctor; J C Hogg
Journal:  Respir Physiol       Date:  1970-01

8.  Fluorocarbons facilitate lung recruitment.

Authors:  Peter N Cox; Helena Frndova; Ove Karlsson; Stephanie Holowka; Charles A Bryan
Journal:  Intensive Care Med       Date:  2003-09-13       Impact factor: 17.440

9.  Optimized dose delivery of the peptide cyclosporine using hydrofluoroalkane-based metered dose inhalers.

Authors:  Paul B Myrdal; Kelly L Karlage; Steve W Stein; Beth A Brown; Alfred Haynes
Journal:  J Pharm Sci       Date:  2004-04       Impact factor: 3.534

10.  Improvement of gas exchange, pulmonary function, and lung injury with partial liquid ventilation. A study model in a setting of severe respiratory failure.

Authors:  R B Hirschl; R Tooley; A C Parent; K Johnson; R H Bartlett
Journal:  Chest       Date:  1995-08       Impact factor: 9.410

View more
  20 in total

1.  A microfluidic model to study fluid dynamics of mucus plug rupture in small lung airways.

Authors:  Yingying Hu; Shiyao Bian; John Grotberg; Marcel Filoche; Joshua White; Shuichi Takayama; James B Grotberg
Journal:  Biomicrofluidics       Date:  2015-08-18       Impact factor: 2.800

2.  Biofluid mechanics of special organs and the issue of system control. Sixth International Bio-Fluid Mechanics Symposium and Workshop, March 28-30, 2008 Pasadena, California.

Authors:  Mair Zamir; James E Moore; Hideki Fujioka; Donald P Gaver
Journal:  Ann Biomed Eng       Date:  2010-03       Impact factor: 3.934

3.  Behavior of liquid plugs at bifurcations in a microfluidic tree network.

Authors:  Nadia Vertti Quintero; Yu Song; Paul Manneville; Charles N Baroud
Journal:  Biomicrofluidics       Date:  2012-07-20       Impact factor: 2.800

Review 4.  Role of airway recruitment and derecruitment in lung injury.

Authors:  Samir Ghadiali; Y Huang
Journal:  Crit Rev Biomed Eng       Date:  2011

Review 5.  Liquid and surfactant delivery into pulmonary airways.

Authors:  David Halpern; Hideki Fujioka; Shuichi Takayama; James B Grotberg
Journal:  Respir Physiol Neurobiol       Date:  2008-05-23       Impact factor: 1.931

6.  Respiratory fluid mechanics.

Authors:  James B Grotberg
Journal:  Phys Fluids (1994)       Date:  2011-02-18       Impact factor: 3.521

7.  The effect of viscoelasticity on the stability of a pulmonary airway liquid layer.

Authors:  David Halpern; Hideki Fujioka; James B Grotberg
Journal:  Phys Fluids (1994)       Date:  2010-01-19       Impact factor: 3.521

8.  Steady Displacement of Long Gas Bubbles in Channels and Tubes Filled by a Bingham Fluid.

Authors:  Parsa Zamankhan; Shuichi Takayama; James B Grotberg
Journal:  Phys Rev Fluids       Date:  2018-01-25       Impact factor: 2.537

9.  Airway reopening through catastrophic events in a hierarchical network.

Authors:  Michael Baudoin; Yu Song; Paul Manneville; Charles N Baroud
Journal:  Proc Natl Acad Sci U S A       Date:  2012-12-31       Impact factor: 11.205

10.  Dynamics of liquid plugs of buffer and surfactant solutions in a micro-engineered pulmonary airway model.

Authors:  Hossein Tavana; Chuan-Hsien Kuo; Qian Yi Lee; Bobak Mosadegh; Dongeun Huh; Paul J Christensen; James B Grotberg; Shuichi Takayama
Journal:  Langmuir       Date:  2010-03-02       Impact factor: 3.882

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.