BACKGROUND: Residual renal function (RRF) affects the survival rate and the development of cardiovascular disease in peritoneal dialysis (PD) patients. We evaluated the impact of RRF on oxidative and carbonyl stress in PD patients. METHODS: Plasma advanced oxidation protein products (AOPP) and pentosidine were measured in PD patients with a urine volume of > or =300 ml/day (group A, n = 17) and <300 ml/day (group B, n = 14). AOPP and pentosidine were reevaluated after 12 months of follow-up in group A. RESULTS: Plasma levels of AOPP and pentosidine in group A were significantly lower than those in group B. Renal creatinine clearance was inversely correlated with AOPP (p < 0.05) and pentosidine (p < 0.01). After 12 months of follow-up, no significant change was observed in AOPP and pentosidine in groups who maintained a urine volume of > or =300 ml/day, but significantly increased in groups whose urine volume decreased to less than 300 ml/day. There were significant inverse relationships between the changes in renal creatinine clearance and AOPP (p < 0.01) and pentosidine (p < 0.05). CONCLUSION: Loss of RRF is associated with increased plasma AOPP and pentosidine, indicating that preservation of RRF has a beneficial effect in reducing the oxidative and carbonyl stress in PD patients. Copyright 2009 S. Karger AG, Basel.
BACKGROUND: Residual renal function (RRF) affects the survival rate and the development of cardiovascular disease in peritoneal dialysis (PD) patients. We evaluated the impact of RRF on oxidative and carbonyl stress in PDpatients. METHODS: Plasma advanced oxidation protein products (AOPP) and pentosidine were measured in PDpatients with a urine volume of > or =300 ml/day (group A, n = 17) and <300 ml/day (group B, n = 14). AOPP and pentosidine were reevaluated after 12 months of follow-up in group A. RESULTS: Plasma levels of AOPP and pentosidine in group A were significantly lower than those in group B. Renal creatinine clearance was inversely correlated with AOPP (p < 0.05) and pentosidine (p < 0.01). After 12 months of follow-up, no significant change was observed in AOPP and pentosidine in groups who maintained a urine volume of > or =300 ml/day, but significantly increased in groups whose urine volume decreased to less than 300 ml/day. There were significant inverse relationships between the changes in renal creatinine clearance and AOPP (p < 0.01) and pentosidine (p < 0.05). CONCLUSION: Loss of RRF is associated with increased plasma AOPP and pentosidine, indicating that preservation of RRF has a beneficial effect in reducing the oxidative and carbonyl stress in PDpatients. Copyright 2009 S. Karger AG, Basel.
Authors: Hong Xu; Makoto Watanabe; Abdul Rashid Qureshi; Olof Heimbürger; Peter Bárány; Björn Anderstam; Monica Eriksson; Peter Stenvinkel; Bengt Lindholm Journal: Perit Dial Int Date: 2014-03-01 Impact factor: 1.756
Authors: Anna Machowska; Jia Sun; Abdul Rashid Qureshi; Naohito Isoyama; Paul Leurs; Björn Anderstam; Olof Heimburger; Peter Barany; Peter Stenvinkel; Bengt Lindholm Journal: PLoS One Date: 2016-10-04 Impact factor: 3.240
Authors: Elena Gonzalez; Maria-Auxiliadora Bajo; Juan J Carrero; Bengt Lindholm; Cristina Grande; Rafael Sánchez-Villanueva; Gloria Del Peso; Mariana Díaz-Almirón; Pedro Iglesias; Juan J Díez; Rafael Selgas Journal: Oxid Med Cell Longev Date: 2015-10-25 Impact factor: 6.543