BACKGROUND/AIMS: Recent studies suggested a role for pro-inflammatory mediators in frontotemporal lobar degeneration (FTLD). The objective of this study was to evaluate the association of functionally active polymorphisms in pro-inflammatory cytokine genes with the occurrence and the clinical features of the disease. METHODS: Using a case-control study, we compared allelic and genotypic frequencies of several polymorphisms in the interleukin (IL)-1alpha, interleukin (IL)-1beta, interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha genes between 110 FTLD patients and 119 healthy controls. RESULTS: No significant association between the examined polymorphisms and the disease was found. However, in comparison with remaining genotypes, patients carrying the T/T genotype of the IL-1beta gene showed a significantly lower age at onset of the disease. In addition, scores of the Frontal Assessment Battery were significantly modified by the IL-6 -174G>C polymorphism. CONCLUSION: Our findings support a role for pro-inflammatory cytokine genes in the pathogenesis of frontotemporal lobar degeneration.
BACKGROUND/AIMS: Recent studies suggested a role for pro-inflammatory mediators in frontotemporal lobar degeneration (FTLD). The objective of this study was to evaluate the association of functionally active polymorphisms in pro-inflammatory cytokine genes with the occurrence and the clinical features of the disease. METHODS: Using a case-control study, we compared allelic and genotypic frequencies of several polymorphisms in the interleukin (IL)-1alpha, interleukin (IL)-1beta, interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha genes between 110 FTLDpatients and 119 healthy controls. RESULTS: No significant association between the examined polymorphisms and the disease was found. However, in comparison with remaining genotypes, patients carrying the T/T genotype of the IL-1beta gene showed a significantly lower age at onset of the disease. In addition, scores of the Frontal Assessment Battery were significantly modified by the IL-6 -174G>C polymorphism. CONCLUSION: Our findings support a role for pro-inflammatory cytokine genes in the pathogenesis of frontotemporal lobar degeneration.
Authors: Virginia Elderkin-Thompson; Michael R Irwin; Gerhard Hellemann; Anand Kumar Journal: Am J Geriatr Psychiatry Date: 2012-09 Impact factor: 4.105
Authors: Katherine Phan; Ying He; Russell Pickford; Surabhi Bhatia; Jared S Katzeff; John R Hodges; Olivier Piguet; Glenda M Halliday; Woojin Scott Kim Journal: Sci Rep Date: 2020-02-27 Impact factor: 4.379
Authors: Elena V Kozlova; Bruno Carabelli; Anthony E Bishay; Rui Liu; Maximillian E Denys; John C Macbeth; Varadh Piamthai; Meli'sa S Crawford; Declan F McCole; Nicole I Zur Nieden; Ansel Hsiao; Margarita C Curras-Collazo Journal: Life Sci Date: 2021-11-18 Impact factor: 6.780