Literature DB >> 19546371

Evaluation of target specificity of antibacterial agents using Staphylococcus aureus ddlA mutants and D-cycloserine in a silkworm infection model.

Kenji Kurokawa1, Hiroshi Hamamoto, Miki Matsuo, Satoshi Nishida, Noriko Yamane, Bok Luel Lee, Kazuhisa Murakami, Hideki Maki, Kazuhisa Sekimizu.   

Abstract

The availability of a silkworm larva infection model to evaluate the therapeutic effectiveness of antibiotics was examined. The 50% effective doses (ED50) of D-cycloserine against the Staphylococcus aureus ddlA mutant-mediated killing of larvae were remarkably lower than those against the parental strain-mediated killing of larvae. Changes in MICs and ED50 of other antibiotics were negligible, suggesting that these alterations are d-cycloserine selective. Therefore, this model is useful for selecting desired compounds based on their therapeutic effectiveness during antibiotic development.

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Year:  2009        PMID： 19546371      PMCID： PMC2737873          DOI： 10.1128/AAC.00200-09

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

1.  THE ENZYMATIC SYNTHESIS OF D-ALANYL-D-ALANINE. 3. ON THE INHIBITION OF D-ALANYL-D-ALANINE SYNTHETASE BY THE ANTIBIOTIC D-CYCLOSERINE.

Authors:  F C NEUHAUS; J L LYNCH
Journal:  Biochemistry       Date:  1964-04       Impact factor: 3.162

2.  Genetic identification of two distinct DNA polymerases, DnaE and PolC, that are essential for chromosomal DNA replication in Staphylococcus aureus.

Authors:  R Inoue; C Kaito; M Tanabe; K Kamura; N Akimitsu; K Sekimizu
Journal:  Mol Genet Genomics       Date:  2001-08-16       Impact factor: 3.291

Review 3.  Antimicrobial-drug resistance.

Authors:  H S Gold; R C Moellering
Journal:  N Engl J Med       Date:  1996-11-07       Impact factor: 91.245

4.  Allosteric inhibition of Staphylococcus aureus D-alanine:D-alanine ligase revealed by crystallographic studies.

Authors:  Shenping Liu; Jeanne S Chang; John T Herberg; Miao-Miao Horng; Paul K Tomich; Alice H Lin; Keith R Marotti
Journal:  Proc Natl Acad Sci U S A       Date:  2006-10-02       Impact factor: 11.205

Review 5.  The emergence and evolution of methicillin-resistant Staphylococcus aureus.

Authors:  K Hiramatsu; L Cui; M Kuroda; T Ito
Journal:  Trends Microbiol       Date:  2001-10       Impact factor: 17.079

6.  Silkworm pathogenic bacteria infection model for identification of novel virulence genes.

Authors:  Chikara Kaito; Kenji Kurokawa; Yasuhiko Matsumoto; Yutaka Terao; Shigetada Kawabata; Shigeyuki Hamada; Kazuhisa Sekimizu
Journal:  Mol Microbiol       Date:  2005-05       Impact factor: 3.501

7.  Mechanism of D-cycloserine action: alanine racemase from Escherichia coli W.

Authors:  M P Lambert; F C Neuhaus
Journal:  J Bacteriol       Date:  1972-06       Impact factor: 3.490

8.  Biochemical characterization of an inhibitor of Escherichia coli UDP-N-acetylmuramyl-l-alanine ligase.

Authors:  David E Ehmann; Julie E Demeritt; Kenneth G Hull; Stewart L Fisher
Journal:  Biochim Biophys Acta       Date:  2004-05-06

9.  Two-component signaling in the virulence of Staphylococcus aureus: a silkworm larvae-pathogenic agent infection model of virulence.

Authors:  Kenji Kurokawa; Chikara Kaito; Kazuhisa Sekimizu
Journal:  Methods Enzymol       Date:  2007       Impact factor: 1.600

10.  Quantitative evaluation of the therapeutic effects of antibiotics using silkworms infected with human pathogenic microorganisms.

Authors:  Hiroshi Hamamoto; Kenji Kurokawa; Chikara Kaito; Koushirou Kamura; Iony Manitra Razanajatovo; Hiroyuki Kusuhara; Tomofumi Santa; Kazuhisa Sekimizu
Journal:  Antimicrob Agents Chemother       Date:  2004-03       Impact factor: 5.191
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  2 in total

1.  Lysocin E is a new antibiotic that targets menaquinone in the bacterial membrane.

Authors:  Hiroshi Hamamoto; Makoto Urai; Kenichi Ishii; Jyunichiro Yasukawa; Atmika Paudel; Motoki Murai; Takuya Kaji; Takefumi Kuranaga; Kenji Hamase; Takashi Katsu; Jie Su; Tatsuo Adachi; Ryuji Uchida; Hiroshi Tomoda; Maki Yamada; Manabu Souma; Hiroki Kurihara; Masayuki Inoue; Kazuhisa Sekimizu
Journal:  Nat Chem Biol       Date:  2014-12-08       Impact factor: 15.040

Review 2.  Advantages of the Silkworm As an Animal Model for Developing Novel Antimicrobial Agents.

Authors:  Suresh Panthee; Atmika Paudel; Hiroshi Hamamoto; Kazuhisa Sekimizu
Journal:  Front Microbiol       Date:  2017-03-07       Impact factor: 5.640
  2 in total

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