| Literature DB >> 1954536 |
N V Ljubimova1, M K Levitman, E D Plotnikova, L Kh Eidus.
Abstract
The dynamics of the endothelial cell population was investigated in the rat brain after local irradiation with different doses of X rays. A fluorescent-histochemical technique was used for the visualization of the cells. A decrease in endothelial cell number was observed within 1 day of irradiation with doses of 5-200 Gy. At this time the endothelial cell number had decreased by up to 15% compared with the pre-treatment values. This early dose-independent loss in cell number was maintained for up to 1 month after irradiation. This was then followed by a slow dose-independent decrease in cell density up to 6 months after exposure. Subsequently the depletion of the endothelial cell population exposed to 40 and 60 Gy continued. After a dose of 25 Gy an abortive recovery of cell numbers occurred followed by an abrupt depletion of the endothelial cell population. The possible mechanisms of such changes are discussed.Entities:
Mesh：
Year: 1991 PMID： 1954536 DOI： 10.1259/0007-1285-64-766-934
Source DB: PubMed Journal: Br J Radiol ISSN： 0007-1285 Impact factor: 3.039