Literature DB >> 19544703

QT interval disturbances in hospitalized elderly patients.

Emilia Lubart1, Refael Segal, Alexandra Yearovoi, Aharon Fridenson, Yehuda Baumoehl, Arthur Leibovitz.   

Abstract

BACKGROUND: The QT interval reflects the total duration of ventricular myocardial repolarization. Its prolongation is associated with increased risk of polymorphic ventricular tachycardia, or torsade de pointes, which can be fatal.
OBJECTIVES: To assess the prevalence of both prolonged and short QT interval in patients admitted to an acute geriatric ward.
METHODS: This retrospective study included the records over 6 months of all patients hospitalized in an acute geriatric ward. Excluded were patients with pacemaker, bundle branch block and slow or rapid atrial fibrillation. The standard 12 lead electrocardiogram of each patient was used for the QT interval evaluation.
RESULTS: We screened the files of 422 patients. QTc prolongation based on the mean of 12 ECG leads was detected in 115 patients (27%). Based on lead L2 only, QTc was prolonged in 136 (32%). Associated factors with QT prolongation were congestive heart failure and use of hypnotics. Short QTwas found in 30 patients (7.1%) in lead L2 and in 19 (4.5%) by the mean 12 leads. Short QT was related to a higher heart rate, chronic atrial fibrillation and schizophrenia.
CONCLUSIONS: Our study detected QT segment disturbances in a considerable number of elderly patients admitted acutely to hospital. Further studies should confirm these results and clinicians should consider a close QT interval follow-up in predisposed patients.

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Year:  2009        PMID: 19544703

Source DB:  PubMed          Journal:  Isr Med Assoc J            Impact factor:   0.892


  6 in total

Review 1.  Reckless administration of QT interval-prolonging agents in elderly patients with drug-induced torsade de pointes.

Authors:  Galia Jackobson; Narin Nard Carmel; Dor Lotan; Anjelika Kremer; Dan Justo
Journal:  Z Gerontol Geriatr       Date:  2016-11-22       Impact factor: 1.281

2.  Providers' Response to Clinical Decision Support for QT Prolonging Drugs.

Authors:  Sunita Sharma; J Martijn Bos; Robert F Tarrell; Gyorgy J Simon; Bruce W Morlan; Michael J Ackerman; Pedro J Caraballo
Journal:  J Med Syst       Date:  2017-09-02       Impact factor: 4.460

3.  Prevalence of QT interval prolongation in patients admitted to cardiac care units and frequency of subsequent administration of QT interval-prolonging drugs: a prospective, observational study in a large urban academic medical center in the US.

Authors:  James E Tisdale; Heather A Wroblewski; Brian R Overholser; Joanna R Kingery; Tate N Trujillo; Richard J Kovacs
Journal:  Drug Saf       Date:  2012-06-01       Impact factor: 5.606

4.  Antipsychotic drug administration does not correlate with prolonged rate-corrected QT interval in children and adolescents: results from a nested case-control study.

Authors:  Christoph U Correll; Jennifer Harris; Vicki Figen; John M Kane; Peter Manu
Journal:  J Child Adolesc Psychopharmacol       Date:  2011-08-08       Impact factor: 2.576

5.  Incidence of Sustained Ventricular Tachycardia in Patients with Prolonged QTc After the Administration of Azithromycin: A Retrospective Study.

Authors:  Steven P Sears; Trevor W Getz; Christopher O Austin; William C Palmer; Evelyn A Boyd; Fernando F Stancampiano
Journal:  Drugs Real World Outcomes       Date:  2016-03

6.  Drug-Associated QTc Prolongation in Geriatric Hospitalized Patients: A Cross-Sectional Study in Internal Medicine.

Authors:  Marco Rossi; Federico Marzi; Mariarita Natale; Aristotele Porceddu; Marco Tuccori; Pietro Enea Lazzerini; Franco Laghi-Pasini; Pier Leopoldo Capecchi
Journal:  Drugs Real World Outcomes       Date:  2021-04-08
  6 in total

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