| Literature DB >> 19543839 |
Lessileia Gomes de Souza1, Jacqueline Miranda de Lima, Ismael Dale Cotrim Guerreiro da Silva, Nora Manoukian Forones.
Abstract
INTRODUCTION: Polymorphism in codon 72, exon 4 of p53 may alter apoptosis and cancer progression. PATIENTS AND METHODS: P53 Arg72Pro genotype was assessed by PCR from 84 gastric cancer patients and 185 controls. The control group was comparable in sex, race, age, smoking, and alcohol intake to the cancer group. RESULTS AND DISCUSSION: There was no difference among the frequency of the alleles or genotypes between the groups. P53 Pro/Pro was associated to a lower risk of metastatic disease (p = 0.02) but not to lymph nodes metastasis or worst prognosis. Arg/Arg or Arg/Pro genotype may be associated to metastatic disease.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19543839 DOI： 10.1007/s12029-009-9078-7
Source DB: PubMed Journal: J Gastrointest Cancer