INTRODUCTION: Most patients suffering from chronic renal insufficiency show impaired carbohydrate metabolism. Our goals were to analyze the accumulated incidence of impaired fasting glucose (IFG) and post-transplant diabetes mellitus (PTDM) after kidney transplantation in our hospital, to assess their impacts on the survival of the graft and of the patient, and to discover the major risk factors for the development of PTDM. MATERIALS AND METHODS: We examined alterations in carbohydrate metabolism in 920 adult patients after they received kidney transplantation. Patients were followed for a minimum period of 5 yr. RESULTS: One year after transplantation, 12.8% of the patients had developed PTDM, and 10.3% showed an IFG level. The IFG had a negative and statistically significant influence on graft and patient survival. Host and donor age, weight, hepatitis C virus infection, and acute rejection were found to be significant risk factors. DISCUSSION: Our study found a high incidence of PTDM, as described in previous studies, but with an emphasis on a greater role played by IFG, not only in its incidence, but also as a prognostic factor for the outcome of graft and patient survival. Identifying patients at risk of developing PTDM is important in offering them early and appropriate treatment.
INTRODUCTION: Most patients suffering from chronic renal insufficiency show impaired carbohydrate metabolism. Our goals were to analyze the accumulated incidence of impaired fasting glucose (IFG) and post-transplant diabetes mellitus (PTDM) after kidney transplantation in our hospital, to assess their impacts on the survival of the graft and of the patient, and to discover the major risk factors for the development of PTDM. MATERIALS AND METHODS: We examined alterations in carbohydrate metabolism in 920 adult patients after they received kidney transplantation. Patients were followed for a minimum period of 5 yr. RESULTS: One year after transplantation, 12.8% of the patients had developed PTDM, and 10.3% showed an IFG level. The IFG had a negative and statistically significant influence on graft and patient survival. Host and donor age, weight, hepatitis C virus infection, and acute rejection were found to be significant risk factors. DISCUSSION: Our study found a high incidence of PTDM, as described in previous studies, but with an emphasis on a greater role played by IFG, not only in its incidence, but also as a prognostic factor for the outcome of graft and patient survival. Identifying patients at risk of developing PTDM is important in offering them early and appropriate treatment.
Authors: F Vincenti; S Friman; E Scheuermann; L Rostaing; T Jenssen; J M Campistol; K Uchida; M D Pescovitz; P Marchetti; M Tuncer; F Citterio; A Wiecek; S Chadban; M El-Shahawy; K Budde; N Goto Journal: Am J Transplant Date: 2007-03-12 Impact factor: 8.086
Authors: Kyu Yeon Hur; Myoung Soo Kim; Yu Seun Kim; Eun Seok Kang; Jae Hyun Nam; So Hun Kim; Chung Mo Nam; Chul Woo Ahn; Bong Soo Cha; Soon Il Kim; Hyun Chul Lee Journal: Diabetes Care Date: 2007-03 Impact factor: 19.112
Authors: Joseph B Muhlestein; Jeffrey L Anderson; Benjamin D Horne; Farangis Lavasani; Chloe A Allen Maycock; Tami L Bair; Robert R Pearson; John F Carlquist Journal: Am Heart J Date: 2003-08 Impact factor: 4.749