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Literature DB >> 1954172

Androgen metabolism in the brain.

Abstract

The paper summarizes the most recent views on androgen metabolism in the brain. In particular it will be shown that: (1) the enzyme 5 alpha-reductase is particularly concentrated in the white matter; (2) 5 alpha-reductase is also present in the myelin; 5 alpha-reductase is present in higher concentrations in neurons (isolated or cultured) that in glial cells (astrocytes and oligodendrocytes); (4) only neurons possess the capability of aromatizing androgens to estrogens; and (5) a possible role of steroid metabolism in the control of the process of myelinogenesis is suggested.

Entities: Chemical

Mesh：

Substances：

Year: 1991 PMID： 1954172 DOI： 10.1016/0960-0760(91)90031-y

Source DB: PubMed Journal: J Steroid Biochem Mol Biol ISSN： 0960-0760 Impact factor: 4.292

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Cited

14 in total

1. Does the degree of endocrine dyscrasia post-reproduction dictate post-reproductive lifespan? Lessons from semelparous and iteroparous species.

Authors: Craig S Atwood; Kentaro Hayashi; Sivan Vadakkadath Meethal; Tina Gonzales; Richard L Bowen
Journal: Geroscience Date: 2017-03-07 Impact factor: 7.713

2. Differential trajectories of neurocognitive functioning in females versus males following treatment for pediatric brain tumors.

Authors: Jesse C Bledsoe; David Breiger; Micah Breiger; Sophia Shonka; Ralph P Ermoian; Jeffrey G Ojemann; David M Werny; Sarah E S Leary; J Russell Geyer
Journal: Neuro Oncol Date: 2019-10-09 Impact factor: 12.300

3. Self-reported neglect, amygdala volume, and symptoms of anxiety in adolescent boys.

Authors: Marissa C Roth; Kathryn L Humphreys; Lucy S King; Ian H Gotlib
Journal: Child Abuse Negl Date: 2018-03-23

4. Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone.

Authors: K A Rose; G Stapleton; K Dott; M P Kieny; R Best; M Schwarz; D W Russell; I Björkhem; J Seckl; R Lathe
Journal: Proc Natl Acad Sci U S A Date: 1997-05-13 Impact factor: 11.205

5. Alterations in glial fibrillary acidic protein (GFAP) mRNA levels in the hamster facial motor nucleus: effects of axotomy and testosterone.

Authors: K J Jones; N B Kinderman; M M Oblinger
Journal: Neurochem Res Date: 1997-11 Impact factor: 3.996

6. Gonadal steroid regulation of growth-associated protein GAP-43 mRNA expression in axotomized hamster facial motor neurons.

Authors: K J Jones; S M Drengler; M M Oblinger
Journal: Neurochem Res Date: 1997-11 Impact factor: 3.996

Androgen metabolism in the brain.

1. Does the degree of endocrine dyscrasia post-reproduction dictate post-reproductive lifespan? Lessons from semelparous and iteroparous species.

2. Differential trajectories of neurocognitive functioning in females versus males following treatment for pediatric brain tumors.

3. Self-reported neglect, amygdala volume, and symptoms of anxiety in adolescent boys.

4. Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone.

5. Alterations in glial fibrillary acidic protein (GFAP) mRNA levels in the hamster facial motor nucleus: effects of axotomy and testosterone.

6. Gonadal steroid regulation of growth-associated protein GAP-43 mRNA expression in axotomized hamster facial motor neurons.

7. Developmental trajectories of amygdala and hippocampus from infancy to early adulthood in healthy individuals.

8. Correlations among brain gray matter volumes, age, gender, and hemisphere in healthy individuals.

Review 9. Safety learning during development: Implications for development of psychopathology.

10. Sex Differences in the Amygdala Resting-State Connectome of Children With Autism Spectrum Disorder.