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Literature DB >> 19541510

Challenges, current status and future perspectives of proteomics in improving understanding, diagnosis and treatment of vascular disease.

J V Moxon¹, M P Padula, B R Herbert, J Golledge.

Abstract

Technical advances have seen the rapid adoption of genomics and multiplex genetic polymorphism identification to research on vascular diseases. The utilization of proteomics for the study of vascular diseases has been limited by comparison. In this review we outline currently available proteomics techniques, the challenges to using these approaches and modifications which may improve the utilization of proteomics in the study of vascular diseases.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Biomarkers
Proteins

Year: 2009 PMID： 19541510 PMCID： PMC2727576 DOI： 10.1016/j.ejvs.2009.05.008

Source DB: PubMed Journal: Eur J Vasc Endovasc Surg ISSN： 1078-5884 Impact factor: 7.069

62 in total

Review 1. Analysing proteomic data.

Authors: J Barrett; P M Brophy; J V Hamilton
Journal: Int J Parasitol Date: 2005-04-30 Impact factor: 3.981

2. Protein markers of ischemic insult in brain endothelial cells identified using 2D gel electrophoresis and ICAT-based quantitative proteomics.

Authors: Arsalan S Haqqani; John Kelly; Ewa Baumann; Reiner F Haseloff; Ingolf E Blasig; Danica B Stanimirovic
Journal: J Proteome Res Date: 2007-01 Impact factor: 4.466

Review 3. Transcriptomics.

Authors: Virendra S Gomase; Somnath Tagore
Journal: Curr Drug Metab Date: 2008-03 Impact factor: 3.731

4. Analysis of mouse brain microvascular endothelium using immuno-laser capture microdissection coupled to a hybrid linear ion trap with Fourier transform-mass spectrometry proteomics platform.

Authors: Qiaozhen Lu; Nivetha Murugesan; Jennifer A Macdonald; Shiaw-Lin Wu; Joel S Pachter; William S Hancock
Journal: Electrophoresis Date: 2008-06 Impact factor: 3.535

5. Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach.

Authors: Mads Grønborg; Troels Zakarias Kristiansen; Akiko Iwahori; Rubens Chang; Raghunath Reddy; Norihiro Sato; Henrik Molina; Ole Nørregaard Jensen; Ralph H Hruban; Michael G Goggins; Anirban Maitra; Akhilesh Pandey
Journal: Mol Cell Proteomics Date: 2005-10-08 Impact factor: 5.911

Review 6. The work of the Human Proteome Organisation's Proteomics Standards Initiative (HUPO PSI).

Authors: Chris F Taylor; Henning Hermjakob; Randall K Julian; John S Garavelli; Ruedi Aebersold; Rolf Apweiler
Journal: OMICS Date: 2006

7. Proteomic analysis of human vessels: application to atherosclerotic plaques.

Authors: Mari Carmen Duran; Sebastian Mas; Jose Luis Martin-Ventura; Olivier Meilhac; Jean Baptiste Michel; Julio Gallego-Delgado; Alberto Lázaro; José Tuñon; Jesus Egido; Fernando Vivanco
Journal: Proteomics Date: 2003-06 Impact factor: 3.984

8. Comparative proteomics analysis of vascular smooth muscle cells incubated with S- and R-enantiomers of atenolol using iTRAQ-coupled two-dimensional LC-MS/MS.

Authors: Jianjun Sui; Jianhua Zhang; Tuan Lin Tan; Chi Bun Ching; Wei Ning Chen
Journal: Mol Cell Proteomics Date: 2008-02-11 Impact factor: 5.911

9. iTRAQ-coupled 2D LC-MS/MS analysis on protein profile in vascular smooth muscle cells incubated with S- and R-enantiomers of propranolol: possible role of metabolic enzymes involved in cellular anabolism and antioxidant activity.

Authors: Jianjun Sui; Tuan Lin Tan; Jianhua Zhang; Chi Bun Ching; Wei Ning Chen
Journal: J Proteome Res Date: 2007-04-11 Impact factor: 4.466

Challenges, current status and future perspectives of proteomics in improving understanding, diagnosis and treatment of vascular disease.

Review 1. Analysing proteomic data.

2. Protein markers of ischemic insult in brain endothelial cells identified using 2D gel electrophoresis and ICAT-based quantitative proteomics.

Review 3. Transcriptomics.

4. Analysis of mouse brain microvascular endothelium using immuno-laser capture microdissection coupled to a hybrid linear ion trap with Fourier transform-mass spectrometry proteomics platform.

5. Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach.

Review 6. The work of the Human Proteome Organisation's Proteomics Standards Initiative (HUPO PSI).

7. Proteomic analysis of human vessels: application to atherosclerotic plaques.

8. Comparative proteomics analysis of vascular smooth muscle cells incubated with S- and R-enantiomers of atenolol using iTRAQ-coupled two-dimensional LC-MS/MS.

9. iTRAQ-coupled 2D LC-MS/MS analysis on protein profile in vascular smooth muscle cells incubated with S- and R-enantiomers of propranolol: possible role of metabolic enzymes involved in cellular anabolism and antioxidant activity.

10. Proteomic analysis of secretory proteins and vesicles in vascular research.

1. In the spotlight: bioinformatics, computational biology and systems biology.

Review 2. Diagnosis and monitoring of abdominal aortic aneurysm: current status and future prospects.

Review 3. Phenomics of Vascular Disease: The Systematic Approach to the Combination Therapy.

Review 4. "Omics"-Informed Drug and Biomarker Discovery: Opportunities, Challenges and Future Perspectives.