| Literature DB >> 19541484 |
Federica Orvieto1, Danila Branca, Claudia Giomini, Philip Jones, Uwe Koch, Jesus M Ontoria, Maria Cecilia Palumbi, Michael Rowley, Carlo Toniatti, Ester Muraglia.
Abstract
A novel series of pyrazolo[1,5-a]quinazolin-5(4H)-one derivatives proved to be a potent class of PARP-1 inhibitors. An extensive SAR around the 3-position of pyrazole in the scaffold led to the discovery of amides derivatives as low nanomolar PARP-1 inhibitors.Entities:
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Year: 2009 PMID： 19541484 DOI： 10.1016/j.bmcl.2009.05.113
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823