Literature DB >> 19541409

5-Aminosalicylic acid inhibits TGF-beta1 signalling in colorectal cancer cells.

Pim J Koelink1, Lukas J A C Hawinkels, Eliza Wiercinska, Cornelis F M Sier, Peter ten Dijke, Cornelis B H W Lamers, Daan W Hommes, Hein W Verspaget.   

Abstract

The transforming growth factor-beta (TGF-beta) pathway is an important pathway in the initiation and progression of colorectal cancer. We aimed to determine the effects of 5-aminosalicylic acid (5-ASA) on TGF-beta signalling in colorectal cancer cells in vitro. 5-ASA inhibited TGF-beta1 signalling in HCT116 cells and colonic fibroblasts, as judged by a TGF-beta-specific reporter gene assay, plasminogen activator inhibitor-1 mRNA and protein levels, fibroblast trans-differentiation, Smad3 phosphorylation and nuclear translocation. We conclude that 5-ASA inhibits TGF-beta1 signalling in colorectal cancer cells, and might be a potent adjuvant therapeutic drug, interfering with aberrant TGF-beta signalling in colorectal cancer. Copyright 2009 Elsevier Ireland Ltd. All rights reserved.

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Year:  2009        PMID： 19541409     DOI： 10.1016/j.canlet.2009.05.033

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  10 in total

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Review 2.  Chemoprevention of colorectal cancer.

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3.  Iridoid glycosides fraction of Folium syringae leaves modulates NF-κB signal pathway and intestinal epithelial cells apoptosis in experimental colitis.

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4.  Anticancer Activity of Water-Soluble Olsalazine-PAMAM-Dendrimer-Salicylic Acid-Conjugates.

Authors:  Sandra Cortez-Maya; Luis Daniel Pedro-Hernández; Elena Martínez-Klimova; Teresa Ramírez-Ápan; Marcos Martínez-García
Journal:  Biomolecules       Date:  2019-08-13

5.  Somatic mutation subtypes of lung adenocarcinoma in East Asian reveal divergent biological characteristics and therapeutic vulnerabilities.

Authors:  Wai-Kok Choong; Ting-Yi Sung
Journal:  iScience       Date:  2021-05-07

6.  Synthesis and evaluation of mutual azo prodrug of 5-aminosalicylic acid linked to 2-phenylbenzoxazole-2-yl-5-acetic acid in ulcerative colitis.

Authors:  Jamal A Jilani; Maha Shomaf; Karem H Alzoubi
Journal:  Drug Des Devel Ther       Date:  2013-07-31       Impact factor: 4.162

7.  Modulation of N-glycosylation by mesalamine facilitates membranous E-cadherin expression in colon epithelial cells.

Authors:  Vineeta Khare; Michaela Lang; Kyle Dammann; Christoph Campregher; Alex Lyakhovich; Christoph Gasche
Journal:  Biochem Pharmacol       Date:  2013-10-30       Impact factor: 5.858

8.  The 5-aminosalicylic acid antineoplastic effect in the intestine is mediated by PPARγ.

Authors:  Christel Rousseaux; Noura El-Jamal; Mathurin Fumery; Caroline Dubuquoy; Olivier Romano; Denis Chatelain; Audrey Langlois; Benjamin Bertin; David Buob; Jean Frederic Colombel; Antoine Cortot; Pierre Desreumaux; Laurent Dubuquoy
Journal:  Carcinogenesis       Date:  2013-07-10       Impact factor: 4.944

9.  Inhibition of breast cancer cell motility with a non-cyclooxygenase inhibitory derivative of sulindac by suppressing TGFβ/miR-21 signaling.

Authors:  Bin Yi; Hong Chang; Ruixia Ma; Xiangling Feng; Wei Li; Gary A Piazza; Yaguang Xi
Journal:  Oncotarget       Date:  2016-02-16

10.  Effect of intra-abdominally administered mesalazine (5-aminosalicylic acid) in experimental peritonitis.

Authors:  Aziz Sener; Alper Sahbaz; Leyla Turker Sener; Merva Soluk Tekkesin; Bulent Kaya
Journal:  North Clin Istanb       Date:  2018-09
  10 in total

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