| Literature DB >> 19540939 |
Liang Guo1, Jianhui Xie, Yuanyuan Ruan, Lei Zhou, Haiyan Zhu, Xiaojing Yun, Yan Jiang, Long Lü, Kangli Chen, Zhihui Min, Yumei Wen, Jianxin Gu.
Abstract
Spores of Ganoderma lucidum contain a large amount of bioactive substances and have a higher bioactivity than the fruit bodies of G. lucidum. However, ingredients from spores are less studied due to the difficulties in collecting the spores and breaking the rigid shell. In this study, a water-soluble polysaccharide named GSG was extracted from the spores of G. lucidum. GSG is characterized to be a branched glucan that contains several different kinds of linkages. It was an effective inducer of MAPKs- and Syk-dependent TNF-alpha and IL-6 secretion in murine resident peritoneal macrophages. Dectin-1 could recognize GSG and partially mediate its biological activities. Additionally, in vivo administration of GSG potentiated the Con A-induced proliferative response of splenocytes and induced anti-tumor activity against Lewis lung cancer in mice. Therefore, these results suggest that GSG is an effective immunomodulator and may be a promising adjuvant remedy for anti-tumor therapies.Entities:
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Year: 2009 PMID： 19540939 DOI： 10.1016/j.intimp.2009.06.005
Source DB: PubMed Journal: Int Immunopharmacol ISSN： 1567-5769 Impact factor: 4.932