| Literature DB >> 19540928 |
Praveensingh B Hajeri1, Sunit Kumar Singh.
Abstract
RNA interference (RNAi) is a novel and essential biological process, as well as a powerful experimental tool with the potential to be used in therapeutic development. RNAi-based strategies have the capability of being able to be driven from bench to bedside. It is very important to develop the precise tools for designing the siRNAs to get the most efficient knockdown of the target genes and to reduce any off-target effects. In this review we have discussed the strategies and parameters required for effective siRNA designing and synthesis, based on already published literature.Mesh：
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Year: 2009 PMID： 19540928 DOI： 10.1016/j.drudis.2009.06.001
Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851