| Literature DB >> 19540664 |
Dan Feng Dong1, En Xiao Li, Ju Bo Wang, Yin Ying Wu, Fan Shi, Jun Jun Guo, Yuan Wu, Jun Ping Liu, Shan Xi Liu, Guang Xiao Yang.
Abstract
Anginex is a novel artificial peptide that can inhibit angiogenesis. AdNT4-anginex was constructed by inserting the artificial anginex gene into a recombinant adenoviral vector. We demonstrated that AdNT4-anginex inhibited migration of human endothelial cells, angiogenesis and tumor growth in in vitro and in vivo studies. Tumor growth of human H22 hepatoma in mice was inhibited after AdNT4-anginex treatment for 4 weeks, and a significant decrease in tumor size was observed as compared with the control group. Overall, these studies indicate that AdNT4-anginex is an effective anti-tumor agent, and deserves more attention and research.Entities:
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Year: 2009 PMID： 19540664 DOI： 10.1016/j.canlet.2009.05.021
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679