Kelly Pagidas1, Sandra A Carson2, Peter G McGovern3, Huiman X Barnhart4, Evan R Myers5, Richard S Legro6, Michael P Diamond7, Bruce R Carr8, William D Schlaff9, Christos Coutifaris10, Michael P Steinkampf11, Nicholas A Cataldo12, John E Nestler13, Gabey Gosman14, Linda C Giudice15. 1. Department of Obstetrics and Gynecology, Warren Alpert Medical School of Brown University, Providence, Rhode Island. Electronic address: kpagidas@wihri.org. 2. Department of Obstetrics and Gynecology, Warren Alpert Medical School of Brown University, Providence, Rhode Island. 3. Department of Obstetrics, Gynecology and Women's Health, University of Medicine and Dentistry, New Jersey-New Jersey Medical School, Newark, New Jersey. 4. Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina. 5. Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina; Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina. 6. Department of Obstetrics and Gynecology, Pennsylvania State University, Hershey, Pennsylvania. 7. Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan. 8. Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas. 9. Department of Obstetrics and Gynecology, University of Colorado, Denver, Colorado. 10. Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. 11. Department of Obstetrics and Gynecology, University of Alabama, Birmingham, Alabama. 12. Stanford University, Palo Alto, California. 13. Department of Medicine, Virginia Commonwealth University School of Medicine. 14. Department of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, Pennsylvania. 15. Reproductive Sciences Branch, National Institute of Child Health and Human Development, Bethesda, Maryland, and Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California.
Abstract
OBJECTIVE: To investigate the relationship among intercourse compliance, ovulation, and the occurrence of pregnancy in the Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome (RMNPPCOS) Trial. DESIGN: Post hoc data analysis of subjects in the Reproductive Medicine Network PPCOS Trial. SETTING:Academic medical centers. INTERVENTION(S): None. PATIENT(S): Six hundred twenty-six infertile women with polycystic ovary syndrome with a mean age of 28.1+/-4 years and mean body mass index of 35.2+/-8.7 kg/m2. MAIN OUTCOME MEASURE(S): Intercourse compliance, ovulation, and pregnancy. RESULT(S): Data on 2925 cycles were included in the analysis, of which 1340 were ovulatory cycles and 1585 were nonovulatory cycles. The rates of intercourse compliance in the PPCOS trial were similar across all treatment groups at all cycles except cycle 4. Among cycles with known ovulation status, 81.2% of patients were compliant with intercourse instructions. Patients were more intercourse compliant in those cycles during which ovulation occurred (83.2% vs. 79.4%). With regard to ovulatory cycles, there was no difference in the occurrence of pregnancy when comparing intercourse compliant versus intercourse noncompliant cycles. CONCLUSION(S): Intercourse compliance was not associated with the occurrence of pregnancy in ovulatory cycles in the PPCOS Trial. The occurrence of ovulation still remains a critical predictor for the occurrence of pregnancy. Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
RCT Entities:
OBJECTIVE: To investigate the relationship among intercourse compliance, ovulation, and the occurrence of pregnancy in the Reproductive Medicine Network's Pregnancy in Polycystic Ovary Syndrome (RMNPPCOS) Trial. DESIGN: Post hoc data analysis of subjects in the Reproductive Medicine Network PPCOS Trial. SETTING: Academic medical centers. INTERVENTION(S): None. PATIENT(S): Six hundred twenty-six infertile women with polycystic ovary syndrome with a mean age of 28.1+/-4 years and mean body mass index of 35.2+/-8.7 kg/m2. MAIN OUTCOME MEASURE(S): Intercourse compliance, ovulation, and pregnancy. RESULT(S): Data on 2925 cycles were included in the analysis, of which 1340 were ovulatory cycles and 1585 were nonovulatory cycles. The rates of intercourse compliance in the PPCOS trial were similar across all treatment groups at all cycles except cycle 4. Among cycles with known ovulation status, 81.2% of patients were compliant with intercourse instructions. Patients were more intercourse compliant in those cycles during which ovulation occurred (83.2% vs. 79.4%). With regard to ovulatory cycles, there was no difference in the occurrence of pregnancy when comparing intercourse compliant versus intercourse noncompliant cycles. CONCLUSION(S): Intercourse compliance was not associated with the occurrence of pregnancy in ovulatory cycles in the PPCOS Trial. The occurrence of ovulation still remains a critical predictor for the occurrence of pregnancy. Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Authors: Richard S Legro; Huiman X Barnhart; William D Schlaff; Bruce R Carr; Michael P Diamond; Sandra A Carson; Michael P Steinkampf; Christos Coutifaris; Peter G McGovern; Nicholas A Cataldo; Gabriella G Gosman; John E Nestler; Linda C Giudice; Phyllis C Leppert; Evan R Myers Journal: N Engl J Med Date: 2007-02-08 Impact factor: 91.245
Authors: Richard S Legro; Allen R Kunselman; Robert G Brzyski; Peter R Casson; Michael P Diamond; William D Schlaff; Gregory M Christman; Christos Coutifaris; Hugh S Taylor; Esther Eisenberg; Nanette Santoro; Heping Zhang Journal: Contemp Clin Trials Date: 2012-01-13 Impact factor: 2.226
Authors: Ankita Prasad; Sunni L Mumford; Germaine M Buck Louis; Katherine A Ahrens; Lindsey A Sjaarda; Karen C Schliep; Neil J Perkins; Kerri A Kissell; Jean Wactawski-Wende; Enrique F Schisterman Journal: Horm Behav Date: 2014-06-20 Impact factor: 3.587
Authors: Richard S Legro; Robert G Brzyski; Michael P Diamond; Christos Coutifaris; William D Schlaff; Ruben Alvero; Peter Casson; Gregory M Christman; Hao Huang; Qingshang Yan; Daniel J Haisenleder; Kurt T Barnhart; G Wright Bates; Rebecca Usadi; Richard Lucidi; Valerie Baker; J C Trussell; Stephen A Krawetz; Peter Snyder; Dana Ohl; Nanette Santoro; Esther Eisenberg; Heping Zhang Journal: Fertil Steril Date: 2013-10-21 Impact factor: 7.329
Authors: Lawrence Engmann; Fangbai Sun; Richard S Legro; Michael P Diamond; Heping Zhang; Nanette Santoro Journal: Hum Reprod Date: 2020-12-01 Impact factor: 6.918