Literature DB >> 19540039

Chemoradiation interactions under reduced oxygen conditions: Cellular characteristics of an in vitro model.

An Wouters1, Bea Pauwels, Hilde A J Lambrechts, Greet G O Pattyn, Johan Ides, Marc Baay, Paul Meijnders, Sylvia Dewilde, Jan B Vermorken, Filip Lardon.   

Abstract

Hypoxic tumour regions often contain viable cells that are more resistant to chemotherapy and/or radiotherapy, making it of key importance to analyse new combination treatments under both normoxic and hypoxic conditions. In this study, the impact of moderate hypoxia and anoxia on cellular characteristics was investigated in isogenic A549 cells differing in p53 status. VEGF expression, doubling time, cell cycle distribution, induction of apoptosis and p53 protein expression were evaluated. Radiation survival curves yielded an oxygen enhancement ratio of 1.16-1.67. In conclusion, an in vitro hypoxia model that will be highly useful to analyse chemoradiation interactions is presented.

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Year:  2009        PMID： 19540039     DOI： 10.1016/j.canlet.2009.05.026

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  11 in total

1.  Tip110 Regulates the Cross Talk between p53 and Hypoxia-Inducible Factor 1α under Hypoxia and Promotes Survival of Cancer Cells.

Authors:  Khalid Amine Timani; Ying Liu; Yan Fan; Khalid S Mohammad; Johnny J He
Journal:  Mol Cell Biol       Date:  2015-05-04       Impact factor: 4.272

2.  Baseline [(18)F]FMISO μPET as a Predictive Biomarker for Response to HIF-1α Inhibition Combined with 5-FU Chemotherapy in a Human Colorectal Cancer Xenograft Model.

Authors:  Sven De Bruycker; Christel Vangestel; Tim Van den Wyngaert; Leonie Wyffels; An Wouters; Patrick Pauwels; Steven Staelens; Sigrid Stroobants
Journal:  Mol Imaging Biol       Date:  2016-08       Impact factor: 3.488

Review 3.  Reciprocal influence of the p53 and the hypoxic pathways.

Authors:  A Sermeus; C Michiels
Journal:  Cell Death Dis       Date:  2011-05-26       Impact factor: 8.469

4.  The hypoxic tumor microenvironment and drug resistance against EGFR inhibitors: preclinical study in cetuximab-sensitive head and neck squamous cell carcinoma cell lines.

Authors:  Carolien Boeckx; Jolien Van den Bossche; Ines De Pauw; Marc Peeters; Filip Lardon; Marc Baay; An Wouters
Journal:  BMC Res Notes       Date:  2015-06-02

5.  The radiosensitising effect of gemcitabine and its main metabolite dFdU under low oxygen conditions is in vitro not dependent on functional HIF-1 protein.

Authors:  An Wouters; Bea Pauwels; Natalie Burrows; Marc Baay; Vanessa Deschoolmeester; Trung Nghia Vu; Kris Laukens; Paul Meijnders; Dirk Van Gestel; Kaye J Williams; Danielle Van den Weyngaert; Jan B Vermorken; Patrick Pauwels; Marc Peeters; Filip Lardon
Journal:  BMC Cancer       Date:  2014-08-16       Impact factor: 4.430

6.  In vitro study of the Polo-like kinase 1 inhibitor volasertib in non-small-cell lung cancer reveals a role for the tumor suppressor p53.

Authors:  Jolien Van den Bossche; Christophe Deben; Ines De Pauw; Hilde Lambrechts; Christophe Hermans; Vanessa Deschoolmeester; Julie Jacobs; Pol Specenier; Patrick Pauwels; Jan Baptist Vermorken; Marc Peeters; Filip Lardon; An Wouters
Journal:  Mol Oncol       Date:  2019-04-05       Impact factor: 6.603

Review 7.  Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses.

Authors:  Joanna Obacz; Silvia Pastorekova; Borek Vojtesek; Roman Hrstka
Journal:  Mol Cancer       Date:  2013-08-14       Impact factor: 27.401

8.  Simultaneous targeting of EGFR, HER2, and HER4 by afatinib overcomes intrinsic and acquired cetuximab resistance in head and neck squamous cell carcinoma cell lines.

Authors:  Ines De Pauw; Filip Lardon; Jolien Van den Bossche; Hasan Baysal; Erik Fransen; Vanessa Deschoolmeester; Patrick Pauwels; Marc Peeters; Jan Baptist Vermorken; An Wouters
Journal:  Mol Oncol       Date:  2018-05-01       Impact factor: 6.603

9.  Cetuximab-induced natural killer cell cytotoxicity in head and neck squamous cell carcinoma cell lines: investigation of the role of cetuximab sensitivity and HPV status.

Authors:  Julie Jacobs; An Wouters; Hasan Baysal; Ines De Pauw; Hannah Zaryouh; Jorrit De Waele; Marc Peeters; Patrick Pauwels; Jan Baptist Vermorken; Evelien Smits; Filip Lardon
Journal:  Br J Cancer       Date:  2020-06-16       Impact factor: 7.640

10.  p53 upregulated by HIF-1α promotes hypoxia-induced G2/M arrest and renal fibrosis in vitro and in vivo.

Authors:  Limin Liu; Peng Zhang; Ming Bai; Lijie He; Lei Zhang; Ting Liu; Zhen Yang; Menglu Duan; Minna Liu; Baojian Liu; Rui Du; Qi Qian; Shiren Sun
Journal:  J Mol Cell Biol       Date:  2019-05-01       Impact factor: 6.216
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