BACKGROUND & AIMS: Chronic obstructive pulmonary disease (COPD) has been recognized as a multi component disease. Currently, limited data are available about determining factors of systemic inflammation in COPD, in particular C-reactive protein (CRP). The aim was to determine whether and to what extent COPD patients with a low, high or obese body mass index (BMI) are more likely to have elevated CRP levels compared to normal-weight COPD patients. Furthermore, we aimed to explore the effects of clinically relevant covariates on the likelihood of having elevated CRP levels. METHODS: In 628 elderly patients with moderate to severe COPD (61% male), lung function and BMI were assessed before entering pulmonary rehabilitation. In addition, blood was collected in the fasted state. High-sensitive C-reactive protein (CRP) was classified into: normal, < or =3; elevated, >3-5 and highly elevated, >5mg/l. RESULTS: Obese COPD patients (BMI> or =30 kg/m(2)) were 3.3 times more likely (95% CI, 1.5-7.0, p=0.002) to have highly elevated CRP levels compared to normal weight (BMI 21-24.9 kg/m(2)) COPD patients after taking clinically relevant confounders into account. In contrast, COPD patients with a low BMI (<21 kg/m(2)) were 2 times less likely (OR, 0.5; 95% CI, 0.3-0.9, p=0.022) to have highly elevated CRP levels compared to normal-weight peers. CONCLUSION: Obese BMI is associated with highly elevated CRP levels in patients with COPD. These findings are suggestive for an adipocyte-induced systemic inflammation in COPD.
BACKGROUND & AIMS:Chronic obstructive pulmonary disease (COPD) has been recognized as a multi component disease. Currently, limited data are available about determining factors of systemic inflammation in COPD, in particular C-reactive protein (CRP). The aim was to determine whether and to what extent COPDpatients with a low, high or obese body mass index (BMI) are more likely to have elevated CRP levels compared to normal-weight COPDpatients. Furthermore, we aimed to explore the effects of clinically relevant covariates on the likelihood of having elevated CRP levels. METHODS: In 628 elderly patients with moderate to severe COPD (61% male), lung function and BMI were assessed before entering pulmonary rehabilitation. In addition, blood was collected in the fasted state. High-sensitive C-reactive protein (CRP) was classified into: normal, < or =3; elevated, >3-5 and highly elevated, >5mg/l. RESULTS:Obese COPDpatients (BMI> or =30 kg/m(2)) were 3.3 times more likely (95% CI, 1.5-7.0, p=0.002) to have highly elevated CRP levels compared to normal weight (BMI 21-24.9 kg/m(2)) COPDpatients after taking clinically relevant confounders into account. In contrast, COPDpatients with a low BMI (<21 kg/m(2)) were 2 times less likely (OR, 0.5; 95% CI, 0.3-0.9, p=0.022) to have highly elevated CRP levels compared to normal-weight peers. CONCLUSION:Obese BMI is associated with highly elevated CRP levels in patients with COPD. These findings are suggestive for an adipocyte-induced systemic inflammation in COPD.
Authors: Mia Moberg; Palchamy Elango; Luigi Ferrucci; Martijn A Spruit; Emiel F Wouters; Erica P A Rutten Journal: Eur J Clin Invest Date: 2015-08-07 Impact factor: 4.686
Authors: Merry-Lynn N McDonald; Alejandro A Diaz; Erica Rutten; Sharon M Lutz; Rola Harmouche; Raul San Jose Estepar; Greg Kinney; John E Hokanson; Barbara A Gower; Emiel F M Wouters; Stephen I Rennard; Craig P Hersh; Richard Casaburi; Mark T Dransfield; Edwin K Silverman; George R Washko Journal: Eur Respir J Date: 2017-12-14 Impact factor: 16.671
Authors: Pilar de Lucas-Ramos; Jose Luis Izquierdo-Alonso; Jose Miguel Rodriguez-Gonzalez Moro; Jesus Fernandez Frances; Paz Vaquero Lozano; Jose M Bellón-Cano Journal: Int J Chron Obstruct Pulmon Dis Date: 2012-10-01
Authors: Martijn A Spruit; Niels H Chavannes; Felix J F Herth; Venerino Poletti; Sebastian Ley; Otto C Burghuber; Enrico Clini; Vincent Cottin Journal: Eur Respir J Date: 2012-03-09 Impact factor: 16.671