| Literature DB >> 19540023 |
Dorota Maciejewska1, Magdalena Rasztawicka, Irena Wolska, Elzbieta Anuszewska, Beata Gruber.
Abstract
A series of 3,3'-dindolylmethane derivatives have been synthesized and their structures were characterized in solid state by (13)C CP/MAS NMR and two of them by X-ray diffraction measurements. They exhibited well expressed cytotoxicity against human melanoma cell lines. Derivatives bearing fluoro, bromo, iodo, and nitro substituents in indole or benzene rings caused 50% inhibition of the viability of ME18 and ME18/R cell lines at concentration ranging 9.7-17.3 microM.Entities:
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Year: 2009 PMID： 19540023 DOI： 10.1016/j.ejmech.2009.05.011
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514