Literature DB >> 19539911

Bone morphogenetic protein-6 stimulates gene expression of follicle-stimulating hormone receptor, inhibin/activin beta subunits, and anti-Müllerian hormone in human granulosa cells.

Jia Shi1, Osamu Yoshino, Yutaka Osuga, Kaori Koga, Yasushi Hirota, Tetsuya Hirata, Tetsu Yano, Osamu Nishii, Yuji Taketani.   

Abstract

Immunohistochemical staining using human normal ovaries showed that bone morphogenetic protein-6 (BMP-6) was abundantly present in the granulosa cells (GC) of healthy tertiary follicles but not in atretic follicles. An in vitro study showed that BMP-6 induced gene expression of FSH receptor, inhibin/activin beta subunits, and anti-Müllerian hormone (AMH) in human GCs, suggesting that BMP-6 is an important mediator to support healthy follicle growth in the human ovary.

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Year:  2009        PMID： 19539911     DOI： 10.1016/j.fertnstert.2009.05.004

Source DB:  PubMed          Journal:  Fertil Steril        ISSN： 0015-0282            Impact factor:   7.329


  21 in total

1.  Bone morphogenetic protein 7 increased vascular endothelial growth factor (VEGF)-a expression in human granulosa cells and VEGF receptor expression in endothelial cells.

Authors:  Ikumi Akiyama; Osamu Yoshino; Yutaka Osuga; Jia Shi; Miyuki Harada; Kaori Koga; Yasushi Hirota; Tetsuya Hirata; Tomoyuki Fujii; Shigeru Saito; Shiro Kozuma
Journal:  Reprod Sci       Date:  2013-09-10       Impact factor: 3.060

2.  The role of bone morphogenetic protein 6 in accumulation and regulation of neutrophils in the human ovary.

Authors:  Ikumi Akiyama; Osamu Yoshino; Yutaka Osuga; Jia Shi; Masashi Takamura; Miyuki Harada; Kaori Koga; Yasushi Hirota; Tetsuya Hirata; Tomoyuki Fujii; Shigeru Saito; Shiro Kozuma
Journal:  Reprod Sci       Date:  2014-01-09       Impact factor: 3.060

3.  The contribution of rare genetic variants to the pathogenesis of polycystic ovary syndrome.

Authors:  Matthew Dapas; Andrea Dunaif
Journal:  Curr Opin Endocr Metab Res       Date:  2020-04-03

Review 4.  The function of bone morphogenetic proteins in the human ovary.

Authors:  Osamu Yoshino; Jia Shi; Yutaka Osuga; Miyuki Harada; Osamu Nishii; Tetsu Yano; Yuji Taketani
Journal:  Reprod Med Biol       Date:  2011-01-06

5.  Family-based quantitative trait meta-analysis implicates rare noncoding variants in DENND1A in polycystic ovary syndrome.

Authors:  Matthew Dapas; Ryan Sisk; Richard S Legro; Margrit Urbanek; Andrea Dunaif; M Geoffrey Hayes
Journal:  J Clin Endocrinol Metab       Date:  2019-04-30       Impact factor: 5.958

6.  Increased bone morphogenetic protein-6 in follicular fluid and granulosa cells may correlate with fertilization and embryo quality in humans.

Authors:  Ying Liang; Qinying Cao; Xing Gao; Huilan Du
Journal:  Exp Ther Med       Date:  2017-06-14       Impact factor: 2.447

7.  Does bone morphogenetic protein 6 (BMP6) affect female fertility in the mouse?

Authors:  Koji Sugiura; You-Qiang Su; John J Eppig
Journal:  Biol Reprod       Date:  2010-08-11       Impact factor: 4.285

Review 8.  Anti-Müllerian hormone: an ovarian reserve marker in primary ovarian insufficiency.

Authors:  Jenny A Visser; Izaäk Schipper; Joop S E Laven; Axel P N Themmen
Journal:  Nat Rev Endocrinol       Date:  2012-01-10       Impact factor: 43.330

9.  FSH and its second messenger cAMP stimulate the transcription of human anti-Müllerian hormone in cultured granulosa cells.

Authors:  Joëlle Taieb; Michaël Grynberg; Alice Pierre; Nassim Arouche; Perrine Massart; Corinne Belville; Laetitia Hesters; René Frydman; Sophie Catteau-Jonard; Renato Fanchin; Jean-Yves Picard; Nathalie Josso; Rodolfo A Rey; Nathalie di Clemente
Journal:  Mol Endocrinol       Date:  2011-02-17

10.  Recombinant Human Bone Morphogenetic Protein 6 Enhances Oocyte Reprogramming Potential and Subsequent Development of the Cloned Yak Embryos.

Authors:  Yangyang Pan; Honghong He; Yan Cui; Abdul Rasheed Baloch; Qin Li; Jiangfeng Fan; Junfeng He; Sijiu Yu
Journal:  Cell Reprogram       Date:  2015-12       Impact factor: 1.987
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