Literature DB >> 19539008

Alpha-glucosidase inhibitory effect of anti-diabetic metal ions and their complexes.

Yutaka Yoshikawa1, Ryoko Hirata, Hiroyuki Yasui, Hiromu Sakurai.   

Abstract

We found alpha-glucosidase inhibitory (alpha-GI) effect of metal ions and their complexes which showed the high blood glucose lowering effect in diabetic model animals. The Cu(II) ion and its complexes showed strong alpha-GI activity greater than clinically used acarbose in in vitro studies. Furthermore, in in vivo experiments, alpha-GI action was newly discovered in normal ddy mice. These results suggested that one of action mechanisms of the anti-diabetic metal ions and complexes is related to the alpha-GI effects.

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Year:  2009        PMID： 19539008     DOI： 10.1016/j.biochi.2009.06.005

Source DB:  PubMed          Journal:  Biochimie        ISSN： 0300-9084            Impact factor:   4.079


  5 in total

1.  A novel series of mixed-ligand M(II) complexes containing 2,2'-bipyridyl as potent α-glucosidase inhibitor: synthesis, crystal structure, DFT calculations, and molecular docking.

Authors:  Davut Avcı; Sümeyye Altürk; Fatih Sönmez; Ömer Tamer; Adil Başoğlu; Yusuf Atalay; Belma Zengin Kurt; Necmi Dege
Journal:  J Biol Inorg Chem       Date:  2019-07-17       Impact factor: 3.358

2.  Novel metal complexes containing 6-methylpyridine-2-carboxylic acid as potent α-glucosidase inhibitor: synthesis, crystal structures, DFT calculations, and molecular docking.

Authors:  Davut Avcı; Sümeyye Altürk; Fatih Sönmez; Ömer Tamer; Adil Başoğlu; Yusuf Atalay; Belma Zengin Kurt; Necmi Dege
Journal:  Mol Divers       Date:  2020-01-21       Impact factor: 2.943

3.  Beneficial Effect of Bis(Hinokitiolato)Zn Complex on High-fat Diet-induced Lipid Accumulation in Mouse Liver and Kidney.

Authors:  Yuki Naito; Yutaka Yoshikawa; Katsuhiko Yoshizawa; Akiko Takenouchi; Hiroyuki Yasui
Journal:  In Vivo       Date:  2017 Nov-Dec       Impact factor: 2.155

Review 4.  Zinc and diabetes mellitus: understanding molecular mechanisms and clinical implications.

Authors:  Priyanga Ranasinghe; Shehani Pigera; Priyadarshani Galappatthy; Prasad Katulanda; Godwin R Constantine
Journal:  Daru       Date:  2015-09-17       Impact factor: 3.117

Review 5.  A review on α-glucosidase inhibitory activity of first row transition metal complexes: a futuristic strategy for treatment of type 2 diabetes.

Authors:  Marzieh Sohrabi; Mohammad Reza Binaeizadeh; Aida Iraji; Bagher Larijani; Mina Saeedi; Mohammad Mahdavi
Journal:  RSC Adv       Date:  2022-04-20       Impact factor: 4.036
  5 in total

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