| Literature DB >> 19539001 |
Folefac Aminkeng1, Jan E Van Autreve, Ilse Weets, Erik Quartier, Chris Van Schravendijk, Frans K Gorus, Bart J Van der Auwera.
Abstract
The evaluation of susceptibility loci in a registry-based setting could be an important addition to the current predictive and screening models in T1D. Therefore, the aim of this study was to evaluate the importance of one of these loci, IFIH1. T1D patients (n=1981), control subjects (n=2092) and 430 families were genotyped for HLA-DQ and IFIH1 nsSNP rs1990760 (Ala946Thr). In the association analysis, the allelic frequencies, A (62.4% vs. 61.3%) and G (37.6% vs. 38.7%) were similar in cases and controls (chi(2) = 0.98, p = 0.32), the genotypic frequencies reveals a weak association with T1D (chi(2) = 6.79, p = 0.03), no significant transmission distortions in families (%T; A = 51.4%, G = 48.0 %, chi(2) = 1.76, p = 0.19) and no interaction with HLA-DQ-linked risk. Furthermore, no genotype-phenotype correlation was observed. In conclusion, IFIH1 has no important role in T1D risk assessment in a registry-based Belgian population.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19539001 DOI： 10.1016/j.humimm.2009.06.013
Source DB: PubMed Journal: Hum Immunol ISSN： 0198-8859 Impact factor: 2.850