Literature DB >> 19538317

A new insight into pathophysiological mechanisms of zinc in diarrhea.

Kazi Mirajul Hoque1, Rafiquel Sarker, Sandra E Guggino, Chung-Ming Tse.   

Abstract

An increasing amount of data showing the beneficial use of zinc (Zn) in treating diarrhea continues to emerge from epidemiological and clinical trials. However, without a thorough understanding of physiological mechanisms of Zn, it does not support policy recommendation to advocate the therapeutic use of Zn. Our data demonstrate that Zn is a potential antidiarrheal agent that provides substantial benefit by stimulating sodium absorption and inhibiting chloride secretion in intestinal epithelial cells. Thus, inclusion of Zn in oral rehydration solution (ORS) has the potential to markedly augment the effectiveness of ORS in the treatment of diarrhea.

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Year:  2009        PMID： 19538317     DOI： 10.1111/j.1749-6632.2009.04442.x

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  13 in total

1.  Epithelial barrier resistance is increased by the divalent cation zinc in cultured MDCKII epithelial monolayers.

Authors:  Georgina Carr; Jamie A Wright; Nicholas L Simmons
Journal:  J Membr Biol       Date:  2010-11-06       Impact factor: 1.843

2.  Zinc ameliorates intestinal barrier dysfunctions in shigellosis by reinstating claudin-2 and -4 on the membranes.

Authors:  Paramita Sarkar; Tultul Saha; Irshad Ali Sheikh; Subhra Chakraborty; Joydeep Aoun; Manoj Kumar Chakrabarti; Vazhaikkurichi M Rajendran; Nadia A Ameen; Shanta Dutta; Kazi Mirajul Hoque
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2018-11-08       Impact factor: 4.052

3.  The Zn2+-sensing receptor, ZnR/GPR39, upregulates colonocytic Cl- absorption, via basolateral KCC1, and reduces fluid loss.

Authors:  Laxmi Sunuwar; Hila Asraf; Mark Donowitz; Israel Sekler; Michal Hershfinkel
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2017-01-16       Impact factor: 5.187

Review 4.  Zinc and gastrointestinal disease.

Authors:  Sonja Skrovanek; Katherine DiGuilio; Robert Bailey; William Huntington; Ryan Urbas; Barani Mayilvaganan; Giancarlo Mercogliano; James M Mullin
Journal:  World J Gastrointest Pathophysiol       Date:  2014-11-15

Review 5.  Glucose transporters in the small intestine in health and disease.

Authors:  Hermann Koepsell
Journal:  Pflugers Arch       Date:  2020-08-23       Impact factor: 3.657

Review 6.  Secretory diarrhoea: mechanisms and emerging therapies.

Authors:  Jay R Thiagarajah; Mark Donowitz; Alan S Verkman
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2015-06-30       Impact factor: 46.802

Review 7.  Oral zinc for treating diarrhoea in children.

Authors:  Marzia Lazzerini; Humphrey Wanzira
Journal:  Cochrane Database Syst Rev       Date:  2016-12-20

Review 8.  Oral rehydration therapy in the second decade of the twenty-first century.

Authors:  Henry J Binder; Ian Brown; B S Ramakrishna; Graeme P Young
Journal:  Curr Gastroenterol Rep       Date:  2014-03

9.  Pathophysiology of Intestinal Na+/H+ exchange.

Authors:  Michael A Gurney; Daniel Laubitz; Fayez K Ghishan; Pawel R Kiela
Journal:  Cell Mol Gastroenterol Hepatol       Date:  2017-01

10.  Zinc deficiency in children with environmental enteropathy-development of new strategies: report from an expert workshop.

Authors:  Graeme P Young; Elissa K Mortimer; Geetha L Gopalsamy; David H Alpers; Henry J Binder; Mark J Manary; Balakrishnan S Ramakrishna; Ian L Brown; Thomas G Brewer
Journal:  Am J Clin Nutr       Date:  2014-08-13       Impact factor: 7.045
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