Literature DB >> 19537931

Glycotoxines, carbonyl stress and relevance to diabetes and its complications.

Z Turk1.   

Abstract

A large body of evidence has implicated reactive carbonyl compounds as glycotoxic mediators of carbonyl stress. This review is focused on the pathophysiological effects of alpha oxoaldehydes in diabetes and related complications, summarizing the state-of-the-art on the endogenously produced carbonyls methylglyoxal, glyoxal and 3-deoxyglucosone, formed as glycolytic intermediates during metabolic conversion of glucose, via Maillard reaction by degradation of glycated proteins, and during lipid peroxidation process. Their role in the advanced glycation process and detrimental effects on vascular tissue are discussed.

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Year:  2009        PMID： 19537931     DOI： 10.33549/physiolres.931585

Source DB:  PubMed          Journal:  Physiol Res        ISSN： 0862-8408            Impact factor:   1.881


  42 in total

1.  Characterisation of glyoxalase I in a streptozocin-induced mouse model of diabetes with painful and insensate neuropathy.

Authors:  M M Jack; J M Ryals; D E Wright
Journal:  Diabetologia       Date:  2011-06-03       Impact factor: 10.122

2.  Advanced oxidation protein products promote NADPH oxidase-dependent β-cell destruction and dysfunction through the Bcl-2/Bax apoptotic pathway.

Authors:  Min Liang; Aiqing Li; Aiju Lou; Xifang Zhang; Youyuan Chen; Lei Yang; Yumin Li; Shenglin Yang; Fan Fan Hou
Journal:  Lab Invest       Date:  2017-03-06       Impact factor: 5.662

Review 3.  Role of advanced glycation endproducts and glyoxalase I in diabetic peripheral sensory neuropathy.

Authors:  Megan Jack; Douglas Wright
Journal:  Transl Res       Date:  2012-01-10       Impact factor: 7.012

4.  Mutagenesis and repair induced by the DNA advanced glycation end product N2-1-(carboxyethyl)-2'-deoxyguanosine in human cells.

Authors:  Daniel Tamae; Punnajit Lim; Gerald E Wuenschell; John Termini
Journal:  Biochemistry       Date:  2011-02-28       Impact factor: 3.162

5.  Carnosine decreased oxidation and glycation products in serum and liver of high-fat diet and low-dose streptozotocin-induced diabetic rats.

Authors:  Abdurrahman Fatih Aydın; İlknur Bingül; Canan Küçükgergin; Işın Doğan-Ekici; Semra Doğru Abbasoğlu; Müjdat Uysal
Journal:  Int J Exp Pathol       Date:  2017-12-04       Impact factor: 1.925

6.  All-Trans Retinoic Acid supplementation prevents cardiac fibrosis and cytokines induced by Methylglyoxal.

Authors:  Umadevi Subramanian; Devipriya Nagarajan
Journal:  Glycoconj J       Date:  2017-01-14       Impact factor: 2.916

7.  The protection conferred against ischemia-reperfusion injury in the diabetic brain by N-acetylcysteine is associated with decreased dicarbonyl stress.

Authors:  Bin Wang; Tak Yee Aw; Karen Y Stokes
Journal:  Free Radic Biol Med       Date:  2016-04-12       Impact factor: 7.376

8.  Relationships between glucose excursion and the activation of oxidative stress in patients with newly diagnosed type 2 diabetes or impaired glucose regulation.

Authors:  Fenping Zheng; Weina Lu; Chengfang Jia; Hong Li; Zhou Wang; Weiping Jia
Journal:  Endocrine       Date:  2010-01-05       Impact factor: 3.633

9.  Aging, Proteotoxicity, Mitochondria, Glycation, NAD and Carnosine: Possible Inter-Relationships and Resolution of the Oxygen Paradox.

Authors:  Alan R Hipkiss
Journal:  Front Aging Neurosci       Date:  2010-03-18       Impact factor: 5.750

10.  PGC-1α regulation of mitochondrial degeneration in experimental diabetic neuropathy.

Authors:  Joungil Choi; Krish Chandrasekaran; Tatsuya Inoue; Anjaneyulu Muragundla; James W Russell
Journal:  Neurobiol Dis       Date:  2014-01-11       Impact factor: 5.996
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