Literature DB >> 1953739

Transforming growth factor-beta up-regulates type VII collagen gene expression in normal and transformed epidermal keratinocytes in culture.

J Ryynänen1, S Sollberg, D R Olsen, J Uitto.   

Abstract

Transforming growth factor-betas (TGF-betas) have been shown to enhance the expression of extracellular matrix genes, including several collagens. In this study, the effects of TGF-beta 1 and TGF-beta 2 on the expression of the gene for type VII collagen, the major component of anchoring fibrils, in human epidermal cell cultures were examined. Incubation of human epidermal keratinocytes or oral epidermoid carcinoma KB cells with TGF-beta 1 or TGF-beta 2 markedly (up to 6.3-fold) elevated the alpha 1(VII) collagen mRNA levels. This elevation was accompanied by enhanced synthesis of type VII collagen, as demonstrated by indirect immunofluorescence with a monoclonal antibody. The results indicate that TGF-beta 1 and TGF-beta 2 have similar biological activities with respect to enhanced type VII collagen gene expression.

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Year:  1991        PMID： 1953739     DOI： 10.1016/s0006-291x(05)81118-0

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  10 in total

Review 1.  Molecular genetics of the cutaneous basement membrane zone. Perspectives on epidermolysis bullosa and other blistering skin diseases.

Authors:  J Uitto; A M Christiano
Journal:  J Clin Invest       Date:  1992-09       Impact factor: 14.808

2.  Genetic linkage of type VII collagen (COL7A1) to dominant dystrophic epidermolysis bullosa in families with abnormal anchoring fibrils.

Authors:  M Ryynänen; J Ryynänen; S Sollberg; R V Iozzo; R G Knowlton; J Uitto
Journal:  J Clin Invest       Date:  1992-03       Impact factor: 14.808

3.  Epidermolysis bullosa. II. Type VII collagen mutations and phenotype-genotype correlations in the dystrophic subtypes.

Authors:  Roslyn Varki; Sara Sadowski; Jouni Uitto; Ellen Pfendner
Journal:  J Med Genet       Date:  2006-09-13       Impact factor: 6.318

4.  Dominant dystrophic epidermolysis bullosa: identification of a Gly-->Ser substitution in the triple-helical domain of type VII collagen.

Authors:  A M Christiano; M Ryynänen; J Uitto
Journal:  Proc Natl Acad Sci U S A       Date:  1994-04-26       Impact factor: 11.205

Review 5.  Type VII collagen: the anchoring fibril protein at fault in dystrophic epidermolysis bullosa.

Authors:  Hye Jin Chung; Jouni Uitto
Journal:  Dermatol Clin       Date:  2010-01       Impact factor: 3.478

6.  Increased invasive behaviour in cutaneous squamous cell carcinoma with loss of basement-membrane type VII collagen.

Authors:  Vera L Martins; Jashmin J Vyas; Mei Chen; Karin Purdie; Charles A Mein; Andrew P South; Alan Storey; John A McGrath; Edel A O'Toole
Journal:  J Cell Sci       Date:  2009-05-12       Impact factor: 5.285

7.  Elevated expression of type VII collagen in the skin of patients with systemic sclerosis. Regulation by transforming growth factor-beta.

Authors:  L Rudnicka; J Varga; A M Christiano; R V Iozzo; S A Jimenez; J Uitto
Journal:  J Clin Invest       Date:  1994-04       Impact factor: 14.808

8.  Transforming growth factor-β in graft vessels: histology and immunohistochemistry.

Authors:  Shi-Min Yuan; Yan-Qing Wang; Yi Shen; Hua Jing
Journal:  Clinics (Sao Paulo)       Date:  2011       Impact factor: 2.365

9.  Aqueous humor TGF-β2 levels in patients with open-angle glaucoma: A meta-analysis.

Authors:  Puneet Agarwal; Aqil Mohammad Daher; Renu Agarwal
Journal:  Mol Vis       Date:  2015-05-25       Impact factor: 2.367

Review 10.  Skin Barrier and Autoimmunity-Mechanisms and Novel Therapeutic Approaches for Autoimmune Blistering Diseases of the Skin.

Authors:  Natalie E Stevens; Allison J Cowin; Zlatko Kopecki
Journal:  Front Immunol       Date:  2019-05-14       Impact factor: 7.561
  10 in total

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