BACKGROUND: Advanced biliary tract adenocarcinoma (BTA) has been a rare but fatal cancer. If unresectable, palliative chemotherapy improved the quality and length of life, but to the authors' knowledge, prognostic factors in such patients have not been well established to date. In the current study, prognostic factors were investigated in patients with advanced BTA receiving first-line palliative chemotherapy. METHODS: Data from 213 patients with advanced BTA who were in prospective phase 2 or retrospective studies from September 2000 through October 2007 were used. RESULTS: With a median follow-up duration of 29.7 months, the median overall survival (OS) was 7.3 months (95% confidence interval [95% CI], 6.3 months-8.3 months). A Cox proportional hazards model indicated that metastatic disease (hazards ratio [HR], 1.521; P=.011), intrahepatic cholangiocellular carcinoma (HR, 1.368; P=.045), liver metastasis (HR, 1.845; P<.001), Eastern Cooperative Oncology Group performance status (HR, 1.707; P<.001), and alkaline phosphatase level (IU/L) (HR, 1.001; P<.001) were statistically significant independent predictors of poor prognosis. Patients were classified into 3 risk groups based on the prognostic index (PI), which was constructed using the regression coefficients of each variable. The median OS was 11.5 months (95% CI, 9.6 months-13.5 months) for the low-risk group (PI<or=1.5; n=67), 7.3 months (95% CI, 5.7 months-8.9 months) for the intermediate-risk group (PI>1.5 but <or=2.2; n=75), and 3.6 months (95% CI, 2.9 months-4.1 months) for the high-risk group (PI>2.2; n=70 [P<.001]). CONCLUSIONS: Five prognostic factors in patients with advanced BTA were identified. The predictive model based on PI appears to be promising and may be used for the management of individual patients and to guide the design of future clinical trials, although external validation is needed. Copyright (c) 2009 American Cancer Society.
BACKGROUND: Advanced biliary tract adenocarcinoma (BTA) has been a rare but fatal cancer. If unresectable, palliative chemotherapy improved the quality and length of life, but to the authors' knowledge, prognostic factors in such patients have not been well established to date. In the current study, prognostic factors were investigated in patients with advanced BTA receiving first-line palliative chemotherapy. METHODS: Data from 213 patients with advanced BTA who were in prospective phase 2 or retrospective studies from September 2000 through October 2007 were used. RESULTS: With a median follow-up duration of 29.7 months, the median overall survival (OS) was 7.3 months (95% confidence interval [95% CI], 6.3 months-8.3 months). A Cox proportional hazards model indicated that metastatic disease (hazards ratio [HR], 1.521; P=.011), intrahepatic cholangiocellular carcinoma (HR, 1.368; P=.045), liver metastasis (HR, 1.845; P<.001), Eastern Cooperative Oncology Group performance status (HR, 1.707; P<.001), and alkaline phosphatase level (IU/L) (HR, 1.001; P<.001) were statistically significant independent predictors of poor prognosis. Patients were classified into 3 risk groups based on the prognostic index (PI), which was constructed using the regression coefficients of each variable. The median OS was 11.5 months (95% CI, 9.6 months-13.5 months) for the low-risk group (PI<or=1.5; n=67), 7.3 months (95% CI, 5.7 months-8.9 months) for the intermediate-risk group (PI>1.5 but <or=2.2; n=75), and 3.6 months (95% CI, 2.9 months-4.1 months) for the high-risk group (PI>2.2; n=70 [P<.001]). CONCLUSIONS: Five prognostic factors in patients with advanced BTA were identified. The predictive model based on PI appears to be promising and may be used for the management of individual patients and to guide the design of future clinical trials, although external validation is needed. Copyright (c) 2009 American Cancer Society.
Authors: Vanessa da Costa Miranda; Maria Ignez Braghiroli; Luiza Dib Batista Bugiato Faria; Sheila Aparecida Coelho Siqueira; Jorge Sabbaga; Paulo M Hoff; Rachel P Riechelmann Journal: J Gastrointest Cancer Date: 2014-03
Authors: Caroline D M Witjes; Henrike E Karim-Kos; Otto Visser; Esther de Vries; Jan N M IJzermans; Robert A de Man; Jan Willem W Coebergh; Cornelis Verhoef Journal: HPB (Oxford) Date: 2012-08-17 Impact factor: 3.647
Authors: Lipika Goyal; Aparna Govindan; Rahul A Sheth; Valentina Nardi; Lawrence S Blaszkowsky; Jason E Faris; Jeffrey W Clark; David P Ryan; Eunice L Kwak; Jill N Allen; Janet E Murphy; Supriya K Saha; Theodore S Hong; Jennifer Y Wo; Cristina R Ferrone; Kenneth K Tanabe; Dawn Q Chong; Vikram Deshpande; Darrell R Borger; A John Iafrate; Nabeel Bardeesy; Hui Zheng; Andrew X Zhu Journal: Oncologist Date: 2015-08-05