Literature DB >> 19535901

Why doesn't Beclin 1, a BH3-only protein, suppress the anti-apoptotic function of Bcl-2?

Iwona A Ciechomska1, Christoph G Goemans, Aviva M Tolkovsky.   

Abstract

Beclin 1 binds to Bcl-2 through its BH3 domain and this interaction inhibits starvation-induced autophagy. However, we have found that when Beclin 1 binds thus to Bcl-2, it fails to inhibit Bcl-2-mediated protection against four different inducers of apoptosis. In this punctum, we discuss possible reasons why Beclin 1 fails to behave like other BH3-only proteins and induce apoptosis.

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Year:  2009        PMID： 19535901     DOI： 10.4161/auto.9096

Source DB:  PubMed          Journal:  Autophagy        ISSN： 1554-8627            Impact factor:   16.016


  10 in total

1.  Targeting Bcl-2-mediated cell death as a novel therapy in pancreatic cancer.

Authors:  Diego J Muilenburg; Jodi M Coates; Subbulakshmi Virudachalam; Richard J Bold
Journal:  J Surg Res       Date:  2010-03-12       Impact factor: 2.192

Review 2.  The crosstalk between autophagy and apoptosis: where does this lead?

Authors:  Claire Gordy; You-Wen He
Journal:  Protein Cell       Date:  2012-02-09       Impact factor: 14.870

3.  Beclin 1/Bcl-2 complex-dependent autophagy activity modulates renal susceptibility to ischemia-reperfusion injury and mediates renoprotection by Klotho.

Authors:  Peng Li; Mingjun Shi; Jenny Maique; Joy Shaffer; Shirley Yan; Orson W Moe; Ming Chang Hu
Journal:  Am J Physiol Renal Physiol       Date:  2020-01-27

4.  Cell death signalling mechanisms in heart failure.

Authors:  Wajihah Mughal; Lorrie A Kirshenbaum
Journal:  Exp Clin Cardiol       Date:  2011

Review 5.  The cellular autophagy/apoptosis checkpoint during inflammation.

Authors:  Jeannette S Messer
Journal:  Cell Mol Life Sci       Date:  2016-11-11       Impact factor: 9.261

6.  Tetraarsenic Hexoxide Induces Beclin-1-Induced Autophagic Cell Death as well as Caspase-Dependent Apoptosis in U937 Human Leukemic Cells.

Authors:  Min Ho Han; Won Sup Lee; Jing Nan Lu; Jeong Won Yun; Gonsup Kim; Jin Myung Jung; Gi-Young Kim; Su-Jae Lee; Wun-Jae Kim; Yung Hyun Choi
Journal:  Evid Based Complement Alternat Med       Date:  2011-09-08       Impact factor: 2.629

Review 7.  Autophagy signal transduction by ATG proteins: from hierarchies to networks.

Authors:  Sebastian Wesselborg; Björn Stork
Journal:  Cell Mol Life Sci       Date:  2015-09-21       Impact factor: 9.261

8.  Resveratrol Activates Autophagy via the AKT/mTOR Signaling Pathway to Improve Cognitive Dysfunction in Rats With Chronic Cerebral Hypoperfusion.

Authors:  Nan Wang; Jinting He; Chengliang Pan; Jiaoqi Wang; Ming Ma; Xinxiu Shi; Zhongxin Xu
Journal:  Front Neurosci       Date:  2019-08-20       Impact factor: 4.677

9.  Mitochondrial impairment in the five-sixth nephrectomy model of chronic renal failure: proteomic approach.

Authors:  Larisa V Fedorova; Anita Tamirisa; David J Kennedy; Steven T Haller; Georgy Budnyy; Joseph I Shapiro; Deepak Malhotra
Journal:  BMC Nephrol       Date:  2013-10-04       Impact factor: 2.388

10.  Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine.

Authors:  D Cai; E Huang; B Luo; Y Yang; F Zhang; C Liu; Z Lin; W-B Xie; H Wang
Journal:  Cell Death Dis       Date:  2016-03-31       Impact factor: 8.469
  10 in total

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