OBJECTIVES: We evaluated the clinical characteristics and risk factors for the paradoxical response (PR) in non-HIV-infected patients with peripheral lymph node tuberculosis (TB). METHODS: Medical records of non-HIV-infected patients aged > or =16 years with peripheral lymph node TB treated in a tertiary hospital between January 1997 and August 2007 were analysed. PR was defined as clinical or radiological worsening of pre-existing TB lesions, or development of new lesions in a patient who had received anti-TB therapy for at least 2 weeks. RESULTS: Three hundred patients with lymph node TB were included. Of these, 235 patients (78%) had confirmed TB; the remaining 65 (22%) had probable TB and were excluded from the final analysis. Among the 235 study patients, their mean age (+/-standard deviation) was 37.6 (+/-13.9) years and 175 (75%) were female. PR occurred in 54 (23%; 95% confidence interval 18-28%) patients, at a median onset time of 8 weeks (interquartile range, 4-14 weeks) after starting anti-TB medication. In multivariate analysis, younger age (OR 0.96), male gender (OR 2.60), and the presence of local tenderness at the time of diagnosis (OR 2.90) were independently associated with PR. CONCLUSION: PR was relatively common, occurring in one-fifth of non-HIV-infected patients with peripheral lymph node TB, and was associated with younger age, male gender, and the presence of local tenderness.
OBJECTIVES: We evaluated the clinical characteristics and risk factors for the paradoxical response (PR) in non-HIV-infectedpatients with peripheral lymph node tuberculosis (TB). METHODS: Medical records of non-HIV-infectedpatients aged > or =16 years with peripheral lymph node TB treated in a tertiary hospital between January 1997 and August 2007 were analysed. PR was defined as clinical or radiological worsening of pre-existing TB lesions, or development of new lesions in a patient who had received anti-TB therapy for at least 2 weeks. RESULTS: Three hundred patients with lymph node TB were included. Of these, 235 patients (78%) had confirmed TB; the remaining 65 (22%) had probable TB and were excluded from the final analysis. Among the 235 study patients, their mean age (+/-standard deviation) was 37.6 (+/-13.9) years and 175 (75%) were female. PR occurred in 54 (23%; 95% confidence interval 18-28%) patients, at a median onset time of 8 weeks (interquartile range, 4-14 weeks) after starting anti-TB medication. In multivariate analysis, younger age (OR 0.96), male gender (OR 2.60), and the presence of local tenderness at the time of diagnosis (OR 2.90) were independently associated with PR. CONCLUSION: PR was relatively common, occurring in one-fifth of non-HIV-infectedpatients with peripheral lymph node TB, and was associated with younger age, male gender, and the presence of local tenderness.
Authors: Hye Seon Kang; Hwa Young Lee; Jung Im Jung; Ju Sang Kim; Yong Hyun Kim; Seung Joon Kim; Seok Chan Kim; Soon Seog Kwon; Young Kyoon Kim; Ji Young Kang Journal: J Thorac Dis Date: 2018-11 Impact factor: 2.895
Authors: Yun Jae Seol; Se Yoon Park; Shi Nae Yu; Tark Kim; Eun Jung Lee; Min Huok Jeon; Eun Ju Choo; Tae Hyong Kim Journal: Infect Chemother Date: 2017-05-24
Authors: Teresa G Martins; Gabriela Trigo; Alexandra G Fraga; José B Gama; Adhemar Longatto-Filho; Margarida Saraiva; Manuel T Silva; António G Castro; Jorge Pedrosa Journal: PLoS Negl Trop Dis Date: 2012-11-29