Literature DB >> 19534584

Prospects for antisense peptide nucleic acid (PNA) therapies for HIV.

Virendra N Pandey1, Alok Upadhyay, Binay Chaubey.   

Abstract

Since the discovery and synthesis of a novel DNA mimic, peptide nucleic acid (PNA) in 1991, PNAs have attracted tremendous interest and have shown great promise as potential antisense drugs. They have been used extensively as tools for specific modulation of gene expression by targeting translation or transcription processes. This review discusses the present and future therapeutic potential of this class of compound as anti-HIV-1 drugs.

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Year:  2009        PMID： 19534584      PMCID： PMC2792880          DOI： 10.1517/14712590903052877

Source DB:  PubMed          Journal:  Expert Opin Biol Ther        ISSN： 1471-2598            Impact factor:   4.388


  105 in total

1.  Anti HIV-1 virucidal activity of polyamide nucleic acid-membrane transducing peptide conjugates targeted to primer binding site of HIV-1 genome.

Authors:  Snehlata Tripathi; Binay Chaubey; Beverly E Barton; Virendra N Pandey
Journal:  Virology       Date:  2007-02-21       Impact factor: 3.616

2.  Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding.

Authors:  L K Clayton; M Sieh; D A Pious; E L Reinherz
Journal:  Nature       Date:  1989-06-15       Impact factor: 49.962

3.  Per-contact risk of human immunodeficiency virus transmission between male sexual partners.

Authors:  E Vittinghoff; J Douglas; F Judson; D McKirnan; K MacQueen; S P Buchbinder
Journal:  Am J Epidemiol       Date:  1999-08-01       Impact factor: 4.897

4.  Human T-cell growth factor (interleukin 2) and gamma-interferon genes: expression in human T-lymphotropic virus type III- and type I-infected cells.

Authors:  S K Arya; R C Gallo
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

5.  Substrate features important for recognition and catalysis by human immunodeficiency virus type 1 integrase identified by using novel DNA substrates.

Authors:  S A Chow; P O Brown
Journal:  J Virol       Date:  1994-06       Impact factor: 5.103

6.  Human immunodeficiency virus type 1 can use different tRNAs as primers for reverse transcription but selectively maintains a primer binding site complementary to tRNA(3Lys).

Authors:  J K Wakefield; A G Wolf; C D Morrow
Journal:  J Virol       Date:  1995-10       Impact factor: 5.103

7.  Small molecules that selectively block RNA binding of HIV-1 Rev protein inhibit Rev function and viral production.

Authors:  M L Zapp; S Stern; M R Green
Journal:  Cell       Date:  1993-09-24       Impact factor: 41.582

8.  Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages.

Authors:  C S Hsieh; S E Macatonia; C S Tripp; S F Wolf; A O'Garra; K M Murphy
Journal:  Science       Date:  1993-04-23       Impact factor: 47.728

9.  An efficient biodelivery system for antisense polyamide nucleic acid (PNA).

Authors:  Mohamed Mehiri; Gregory Upert; Snehlata Tripathi; Audrey Di Giorgio; Roger Condom; Virendra N Pandey; Nadia Patino
Journal:  Oligonucleotides       Date:  2008-09

10.  Synthetic peptides derived from the variable regions of an anti-CD4 monoclonal antibody bind to CD4 and inhibit HIV-1 promoter activation in virus-infected cells.

Authors:  C Monnet; D Laune; J Laroche-Traineau; M Biard-Piechaczyk; L Briant; C Bès; M Pugnière; J C Mani; B Pau; M Cerutti; G Devauchelle; C Devaux; C Granier; T Chardès
Journal:  J Biol Chem       Date:  1999-02-05       Impact factor: 5.157
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  8 in total

1.  A peptide nucleic acid-aminosugar conjugate targeting transactivation response element of HIV-1 RNA genome shows a high bioavailability in human cells and strongly inhibits tat-mediated transactivation of HIV-1 transcription.

Authors:  Indrajit Das; Jérôme Désiré; Dinesh Manvar; Isabelle Baussanne; Virendra N Pandey; Jean-Luc Décout
Journal:  J Med Chem       Date:  2012-06-22       Impact factor: 7.446

2.  Uptake by human glioma cell lines and biological effects of a peptide-nucleic acids targeting miR-221.

Authors:  Eleonora Brognara; Enrica Fabbri; Elena Bazzoli; Giulia Montagner; Claudio Ghimenton; Albino Eccher; Cinzia Cantù; Alex Manicardi; Nicoletta Bianchi; Alessia Finotti; Giulia Breveglieri; Monica Borgatti; Roberto Corradini; Valentino Bezzerri; Giulio Cabrini; Roberto Gambari
Journal:  J Neurooncol       Date:  2014-03-05       Impact factor: 4.130

3.  Inhibition of HIV Replication by Cyclic and Hairpin PNAs Targeting the HIV-1 TAR RNA Loop.

Authors:  Gregory Upert; Audrey Di Giorgio; Alok Upadhyay; Dinesh Manvar; Nootan Pandey; Virendra N Pandey; Nadia Patino
Journal:  J Nucleic Acids       Date:  2012-09-17

4.  Artificial Activation of Escherichia coli mazEF and hipBA Toxin-Antitoxin Systems by Antisense Peptide Nucleic Acids as an Antibacterial Strategy.

Authors:  Marcin Równicki; Tomasz Pieńko; Jakub Czarnecki; Monika Kolanowska; Dariusz Bartosik; Joanna Trylska
Journal:  Front Microbiol       Date:  2018-11-26       Impact factor: 5.640

5.  Targeting miR‑155‑5p and miR‑221‑3p by peptide nucleic acids induces caspase‑3 activation and apoptosis in temozolomide‑resistant T98G glioma cells.

Authors:  Roberta Milani; Eleonora Brognara; Enrica Fabbri; Alex Manicardi; Roberto Corradini; Alessia Finotti; Jessica Gasparello; Monica Borgatti; Lucia Carmela Cosenza; Ilaria Lampronti; Maria Cristina Dechecchi; Giulio Cabrini; Roberto Gambari
Journal:  Int J Oncol       Date:  2019-05-23       Impact factor: 5.650

6.  Therapeutic effects, immunogenicity and cytotoxicity of a cell penetrating peptide-peptide nucleic acid conjugate against cagA of Helicobacter pylori in cell culture and animal model.

Authors:  Narges Nodeh Farahani; Behrooz Sadeghi Kalani; Seyed Hamidreza Monavari; Shiva Mirkalantari; Fatemeh Montazer; Mohammad Sholeh; Zahra Javanmard; Gholamreza Irajian
Journal:  Iran J Microbiol       Date:  2021-06

7.  Demonstrating specificity of bioactive peptide nucleic acids (PNAs) targeting microRNAs for practical laboratory classes of applied biochemistry and pharmacology.

Authors:  Jessica Gasparello; Chiara Papi; Matteo Zurlo; Roberto Corradini; Roberto Gambari; Alessia Finotti
Journal:  PLoS One       Date:  2019-09-11       Impact factor: 3.240

8.  Peptide-mediated Cell and In Vivo Delivery of Antisense Oligonucleotides and siRNA.

Authors:  Peter Järver; Thibault Coursindel; Samir El Andaloussi; Caroline Godfrey; Matthew Ja Wood; Michael J Gait
Journal:  Mol Ther Nucleic Acids       Date:  2012-06-12       Impact factor: 10.183
  8 in total

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