Literature DB >> 195338

Modulation of macrophage tumoricidal capability by components of normal serum: a central role for lipid.

H A Chapman, J B Hibbs.   

Abstract

The tumoricidal capabilities of macrophages can be reversibly inhibited by a lipoprotein of high molecular weight, and the inhibition appears to be reproduced by enrichment of macrophage plasma membranes with cholesterol. A second serum component of lower molecular weight enhances macrophage cytotoxicity. The presence of these components in normal serums suggests a physiological role for such factors in the regulation of macrophage function.

Entities:  

Mesh：

Substances：

Year:  1977        PMID： 195338     DOI： 10.1126/science.195338

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  20 in total

1.  Extraction of skin test activity from Coccidioides immitis mycelia by water, perchloric acid, and aqueous phenol extraction.

Authors:  R W Wheat; K S Su Chung; E P Ornellas; E R Scheer
Journal:  Infect Immun       Date:  1978-01       Impact factor: 3.441

2.  Fluidity-dependent Mg2(+)-ATPase activity in membranes from Leishmania donovani promastigotes.

Authors:  M Dutta; R Bandyopadhyay; C Ghosh; M K Basu
Journal:  Biochem J       Date:  1990-02-01       Impact factor: 3.857

3.  Modulation of plasminogen activator secretion by activated macrophages: influence of serum factors and correlation with tumoricidal potential.

Authors:  H A Chapman; Z Vavrin; J B Hibbs
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

4.  Modulation of macrophage tumoricidal capability by polyene antibiotics: support for membrane lipid as a regulatory determinant of macrophage function.

Authors:  H A Chapman; J B Hibbs
Journal:  Proc Natl Acad Sci U S A       Date:  1978-09       Impact factor: 11.205

5.  Plasma lipoprotein induction and suppression of the generation of cellular procoagulant activity in vitro.

Authors:  G A Levy; B S Schwartz; L K Curtiss; T S Edgington
Journal:  J Clin Invest       Date:  1981-06       Impact factor: 14.808

6.  Kinetics and ultrastructural studies of the induction of rat alveolar macrophage fusion by mediators released from mitogen-stimulated lymphocytes.

Authors:  S Sone; C Bucana; L C Hoyer; I J Fidler
Journal:  Am J Pathol       Date:  1981-05       Impact factor: 4.307

7.  Inhibition of host resistance by nutritional hypercholesteremia.

Authors:  W L Kos; R M Loria; M J Snodgrass; D Cohen; T G Thorpe; A M Kaplan
Journal:  Infect Immun       Date:  1979-11       Impact factor: 3.441

8.  Human serum induces maturation of human monocytes in vitro. Changes in cytolytic activity, intracellular lysosomal enzymes, and nonspecific esterase activity.

Authors:  R A Musson
Journal:  Am J Pathol       Date:  1983-06       Impact factor: 4.307

9.  Role of membrane lipids in the immunological killing of tumor cells: II. Effector cell lipids.

Authors:  S I Schlager; M S Meltzer; L D Madden
Journal:  Lipids       Date:  1983-07       Impact factor: 1.880

10.  Antibody-dependent and -independent cytotoxicity of human mononuclear phagocytes: defective stimulation of tumoricidal activity in milk macrophages.

Authors:  A Biondi; G Peri; N Colombo; G Bolis; A Mantovani
Journal:  Clin Exp Immunol       Date:  1982-09       Impact factor: 4.330
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.