Literature DB >> 19533661

Non-Hodgkin lymphoma following temozolomide.

Atul Sharma1, Deepak Gupta, B K Mohanti, Sanjay Thulkar, Amit Dwary, Shikha Goyal, Sandeep Muzumder, Prasenjit Das.   

Abstract

Temozolomide (TMZ) is an oral alkylating agent with significant activity against glioblastoma multiforme (GBM) and melanoma. It increases survival by 2.5 months when used in combination with radiotherapy as an adjuvant therapy in GBM. Secondary MDS/AML or non-Hodgkin lymphoma attributed to TMZ exposure has been reported. We report a case of non-Hodgkin lymphoma secondary to temozolomide in a 20-year-old female who was treated for GBM with concurrent TMZ and radiotherapy. She developed lymphoma 2 months after completing chemoradiotherapy. Although she was treated with combination chemotherapy for lymphoma, she died of progressive GBM.

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Year:  2009        PMID： 19533661     DOI： 10.1002/pbc.22090

Source DB:  PubMed          Journal:  Pediatr Blood Cancer        ISSN： 1545-5009            Impact factor:   3.167


  5 in total

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5.  Non-hodgkin lymphoma after treatment with extended dosing temozolomide and radiotherapy for a glioblastoma: a case report.

Authors:  Laura Van Ginderachter; Tony Cox; Ria Drijkoningen; Ruth Achten; Eric Joosens; Annelies Maes; Koen Theunissen; Jeroen Mebis
Journal:  Case Rep Oncol       Date:  2013-01-19
  5 in total

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