OBJECTIVE: The prognostic significance of serum carcinoembryonic antigen (CEA) levels in non-small-cell lung cancer (NSCLC) patients with a normal serum CEA level (<5.0 ng/ml) was examined. METHODS: A total of 220 consecutive NSCLC patients with preoperative normal serum CEA levels were included. Patients were subdivided into two groups: preoperative serum CEA level >/=2.5 and <2.5 ng/ml. RESULTS: The 5-year survival of patients with preoperative serum CEA level less and more than 2.5 ng/ml were 79.62% and 62.0%, respectively (P = 0.0036). Multivariate analysis indicated that a preoperative serum CEA level of >/=2.5 ng/ml was an independent prognostic factor. Similar results were found in patients with adenocarcinoma but not found in others. CONCLUSION: NSCLC patients with a high serum CEA level, especially adenocarcinoma patients, had poorer prognosis even if their serum CEA levels were within the normal upper limit.
OBJECTIVE: The prognostic significance of serum carcinoembryonic antigen (CEA) levels in non-small-cell lung cancer (NSCLC) patients with a normal serum CEA level (<5.0 ng/ml) was examined. METHODS: A total of 220 consecutive NSCLCpatients with preoperative normal serum CEA levels were included. Patients were subdivided into two groups: preoperative serum CEA level >/=2.5 and <2.5 ng/ml. RESULTS: The 5-year survival of patients with preoperative serum CEA level less and more than 2.5 ng/ml were 79.62% and 62.0%, respectively (P = 0.0036). Multivariate analysis indicated that a preoperative serum CEA level of >/=2.5 ng/ml was an independent prognostic factor. Similar results were found in patients with adenocarcinoma but not found in others. CONCLUSION:NSCLCpatients with a high serum CEA level, especially adenocarcinomapatients, had poorer prognosis even if their serum CEA levels were within the normal upper limit.
Authors: K Hotta; Y Segawa; N Takigawa; D Kishino; H Saeki; M Nakata; K Mandai; K Eguchi Journal: Anticancer Res Date: 2000 May-Jun Impact factor: 2.480
Authors: J P Concannon; M H Dalbow; S E Hodgson; J J Headings; E Markopoulos; J Mitchell; W J Cushing; G A Liebler Journal: Cancer Date: 1978-09 Impact factor: 6.860
Authors: Dong Guo; Wang Jing; Hui Zhu; Minghuan Li; Bing Zou; Yan Zhang; Lei Fu; Li Kong; Jinbo Yue; Jinming Yu Journal: Cancer Manag Res Date: 2018-09-04 Impact factor: 3.989