PURPOSE: Although survival has been studied for various subtypes of non-Hodgkin's lymphoma (NHL), there have been few comprehensive studies to quantify the prognosis, including all specific histologies. The effect of family history on survival in NHL has not been examined. METHODS: We used the Swedish Family-Cancer Database to estimate hazard ratios in NHL by histology and family history. RESULTS: Using diffuse centroblastic lymphoma as reference (HR 1.0), patients with Waldenström's macroglobulinemia and hairy-cell leukemia had the best survival. Survival advantage was also noted among patients with lymphoplasmacytic lymphoma and different kinds of follicular lymphomas. For T-cell lymphoma, mycosis fungoides showed a favorable prognosis. As for survival by family history, a total of 98 familial cases were noted in our Database with a similar prognosis compared to sporadic cases in both parental and offspring generations. A non-significant familial concordance of either good or poor survival was noted among family members when probands' prognosis was stratified by survival time. CONCLUSIONS: Our results provide quantitative prognosis data for patients with NHL according to specific histologies. Patients with a familial NHL had a similar prognosis compared to patients with sporadic disease. The data suggest familial concordance in either good or poor survival among family members.
PURPOSE: Although survival has been studied for various subtypes of non-Hodgkin's lymphoma (NHL), there have been few comprehensive studies to quantify the prognosis, including all specific histologies. The effect of family history on survival in NHL has not been examined. METHODS: We used the Swedish Family-Cancer Database to estimate hazard ratios in NHL by histology and family history. RESULTS: Using diffuse centroblastic lymphoma as reference (HR 1.0), patients with Waldenström's macroglobulinemia and hairy-cell leukemia had the best survival. Survival advantage was also noted among patients with lymphoplasmacytic lymphoma and different kinds of follicular lymphomas. For T-cell lymphoma, mycosis fungoides showed a favorable prognosis. As for survival by family history, a total of 98 familial cases were noted in our Database with a similar prognosis compared to sporadic cases in both parental and offspring generations. A non-significant familial concordance of either good or poor survival was noted among family members when probands' prognosis was stratified by survival time. CONCLUSIONS: Our results provide quantitative prognosis data for patients with NHL according to specific histologies. Patients with a familial NHL had a similar prognosis compared to patients with sporadic disease. The data suggest familial concordance in either good or poor survival among family members.
Authors: Kari Hemminki; Charlotta Granström; Jan Sundquist; Justo Lorenzo Bermejo Journal: Hered Cancer Clin Pract Date: 2006-12-15 Impact factor: 2.857
Authors: Eleazar Hernandez-Ruiz; Martha Alvarado-Ibarra; Lourdes Esthela Juan Lien-Chang; Luisa Banda-Garcia; Jorge Luis Aquino-Salgado; Gabriel Barragan-Ibanez; Eva Fabiola Ramirez-Romero; Cesar Nolasco-Cancino; Wilfrido Herrera-Olivares; Javier de Jesus Morales-Adrian; Eugenia Patricia Paredes-Lozano; Maria Eugenia Espitia-Rios; Maria de Monserrat Gonzalez Lopez-Elizalde; Jose Luis Lopez-Arroyo; Jorge Enrique Trejo-Gomora; Jose Antonio De la Pena-Celaya; Jose Luis Alvarez-Vera; Luara Luz Arana-Luna; Annel Martinez-Rios; Rodrigo Resendiz-Olea; Lucero Jazmin Rodriguez-Velasquez; Nidia Zapata-Canto; Juan Manuel Perez-Zuniga Journal: World J Oncol Date: 2021-02-24
Authors: Fredrik Baecklund; Sara Ekberg; Richard Rosenquist; Johan Askling; Sandra Eloranta; Karin E Smedby Journal: Eur J Haematol Date: 2020-09-29 Impact factor: 2.997