BACKGROUND: The aim of this study was to evaluate the incidence and risk factors associated with anastomotic leakage after colon cancer surgery using data compiled in the nationwide German qualitative multi-center study "Colon/Rectum Cancer" (WGCRC). METHODS: From 01/01/2000 to 12/31/2004 data recorded from patients with anastomotic leakages were evaluated to determine independent predictors of leakage using logistic regression analysis. RESULTS: A total of 28,271 patients underwent colon resection with anastomoses and anastomotic leaks occurred in 3.0% (n=844). Multivariate analysis identified long duration of surgery, a high ASA score, male gender, obstruction, left-sided tumor, cardiovascular hepatic comorbidity, single-layer hand suture, anastomoses using the biofragmentable Valtrac ring, intraoperative complications and BMI>30 kg/m(2) as risk factors for postoperative occurrence of anastomotic leakage. CONCLUSIONS: Even though the rate of anastomotic leaks in patients with anastomoses after resection for colon cancer is low, it remains a significant complication, associated with significant morbidity and mortality. The knowledge of risk factors should be considered in perioperative decision-making regarding anastomotic technique and indications for Hartmann's procedure.
BACKGROUND: The aim of this study was to evaluate the incidence and risk factors associated with anastomotic leakage after colon cancer surgery using data compiled in the nationwide German qualitative multi-center study "Colon/Rectum Cancer" (WGCRC). METHODS: From 01/01/2000 to 12/31/2004 data recorded from patients with anastomotic leakages were evaluated to determine independent predictors of leakage using logistic regression analysis. RESULTS: A total of 28,271 patients underwent colon resection with anastomoses and anastomotic leaks occurred in 3.0% (n=844). Multivariate analysis identified long duration of surgery, a high ASA score, male gender, obstruction, left-sided tumor, cardiovascular hepatic comorbidity, single-layer hand suture, anastomoses using the biofragmentable Valtrac ring, intraoperative complications and BMI>30 kg/m(2) as risk factors for postoperative occurrence of anastomotic leakage. CONCLUSIONS: Even though the rate of anastomotic leaks in patients with anastomoses after resection for colon cancer is low, it remains a significant complication, associated with significant morbidity and mortality. The knowledge of risk factors should be considered in perioperative decision-making regarding anastomotic technique and indications for Hartmann's procedure.
Authors: Sang Hun Jung; Chang Sik Yu; Pyong Wha Choi; Dae Dong Kim; In Ja Park; Hee Cheol Kim; Jin Cheon Kim Journal: Dis Colon Rectum Date: 2008-04-12 Impact factor: 4.585
Authors: M L Cossu; M Coppola; E Fais; M Ruggiu; C Spartà; S Profili; V Bifulco; G B Meloni; G Noya Journal: Am Surg Date: 2000-08 Impact factor: 0.688
Authors: Kenneth G Walker; Stephen W Bell; Matthew J F X Rickard; Daniel Mehanna; Owen F Dent; Pierre H Chapuis; E Leslie Bokey Journal: Ann Surg Date: 2004-08 Impact factor: 12.969
Authors: Benjamin D Shogan; Gary C An; Hans M Schardey; Jeffrey B Matthews; Konstantin Umanskiy; James W Fleshman; Jens Hoeppner; Donald E Fry; Eduardo Garcia-Granereo; Hans Jeekel; Harry van Goor; E Patchen Dellinger; Vani Konda; Jack A Gilbert; Gregory W Auner; John C Alverdy Journal: Surg Infect (Larchmt) Date: 2014-09-12 Impact factor: 2.150
Authors: S A Rojas-Machado; M Romero-Simó; A Arroyo; A Rojas-Machado; J López; R Calpena Journal: Int J Colorectal Dis Date: 2015-10-27 Impact factor: 2.571