Literature DB >> 19532864

Structure of the Michaelis complex of beta-mannosidase, Man2A, provides insight into the conformational itinerary of mannoside hydrolysis.

Wendy A Offen1, David L Zechel, Stephen G Withers, Harry J Gilbert, Gideon J Davies.   

Abstract

The Michaelis complex of the beta-mannosidase Man2A shows distortion to a (1)S(5) conformation adding to the growing body of evidence supporting catalysis through a boat conformation.

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Year:  2009        PMID： 19532864     DOI： 10.1039/b902240f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  6 in total

1.  Mechanistic insights into a Ca2+-dependent family of alpha-mannosidases in a human gut symbiont.

Authors:  Yanping Zhu; Michael D L Suits; Andrew J Thompson; Sambhaji Chavan; Zoran Dinev; Claire Dumon; Nicola Smith; Kelley W Moremen; Yong Xiang; Aloysius Siriwardena; Spencer J Williams; Harry J Gilbert; Gideon J Davies
Journal:  Nat Chem Biol       Date:  2009-12-27       Impact factor: 15.040

2.  2'-Fluoro substituents can mimic native 2'-hydroxyls within structured RNA.

Authors:  Marcello Forconi; Jason P Schwans; Rishi H Porecha; Raghuvir N Sengupta; Joseph A Piccirilli; Daniel Herschlag
Journal:  Chem Biol       Date:  2011-08-26

3.  Combined inhibitor free-energy landscape and structural analysis reports on the mannosidase conformational coordinate.

Authors:  Rohan J Williams; Javier Iglesias-Fernández; Judith Stepper; Adam Jackson; Andrew J Thompson; Elisabeth C Lowe; Jonathan M White; Harry J Gilbert; Carme Rovira; Gideon J Davies; Spencer J Williams
Journal:  Angew Chem Int Ed Engl       Date:  2013-12-11       Impact factor: 15.336

4.  Expression of a β-mannosidase from Paenibacillus polymyxa A-8 in Escherichia coli and characterization of the recombinant enzyme.

Authors:  Xi Bai; Hong Hu; Huaping Chen; Quanbin Wei; Zeshen Yang; Qianming Huang
Journal:  PLoS One       Date:  2014-11-25       Impact factor: 3.240

5.  Bacteroides thetaiotaomicron generates diverse α-mannosidase activities through subtle evolution of a distal substrate-binding motif.

Authors:  Andrew J Thompson; Richard J Spears; Yanping Zhu; Michael D L Suits; Spencer J Williams; Harry J Gilbert; Gideon J Davies
Journal:  Acta Crystallogr D Struct Biol       Date:  2018-04-24       Impact factor: 7.652

6.  Host glycan utilization within the Bacteroidetes Sus-like paradigm.

Authors:  Haley A Brown; Nicole M Koropatkin
Journal:  Glycobiology       Date:  2021-06-29       Impact factor: 4.313
  6 in total

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