Gabrielle Williams1, Jonathan C Craig. 1. Centre for Kidney Research, The Children's Hospital at Westmead, Westmead, Australia. gabriew4@cw.edu.au
Abstract
PURPOSE OF REVIEW: Urinary tract infection (UTI) in children is common (5-10%) and recurs in 10-30%. UTI causes an unpleasant, usually febrile illness in children. This review focuses on studies evaluating interventions to prevent UTI in children and published between January 2007 and June 2008. RECENT FINDINGS: Three relevant updated Cochrane reviews, six randomized trials and an evidence-based guideline were published in the study period. Five of the six trials and one of the three Cochrane updates included data on the effects of relevant interventions in children. Three of the six trials investigated the efficacy of long-term, low-dose antibiotics as prophylaxis, and the other trials and both Cochrane updates evaluated complementary therapies such as vitamin A, probiotics and herbal supplements. SUMMARY: The benefit of prophylactic antibiotics for the prevention of recurrent UTI in children remains unclear because of underpowered and suboptimally designed trials, but these studies suggest that any benefit is likely to be small, and clinical significance may be limited. The trials of complementary interventions (vitamin A, probiotics, cranberry, nasturtium and horseradish) generally gave favourable results but were not conclusive. Children and families who use these products should be aware that further infections are possible despite their use.
PURPOSE OF REVIEW: Urinary tract infection (UTI) in children is common (5-10%) and recurs in 10-30%. UTI causes an unpleasant, usually febrile illness in children. This review focuses on studies evaluating interventions to prevent UTI in children and published between January 2007 and June 2008. RECENT FINDINGS: Three relevant updated Cochrane reviews, six randomized trials and an evidence-based guideline were published in the study period. Five of the six trials and one of the three Cochrane updates included data on the effects of relevant interventions in children. Three of the six trials investigated the efficacy of long-term, low-dose antibiotics as prophylaxis, and the other trials and both Cochrane updates evaluated complementary therapies such as vitamin A, probiotics and herbal supplements. SUMMARY: The benefit of prophylactic antibiotics for the prevention of recurrent UTI in children remains unclear because of underpowered and suboptimally designed trials, but these studies suggest that any benefit is likely to be small, and clinical significance may be limited. The trials of complementary interventions (vitamin A, probiotics, cranberry, nasturtium and horseradish) generally gave favourable results but were not conclusive. Children and families who use these products should be aware that further infections are possible despite their use.
Authors: N L Ramos; D T N Dzung; K Stopsack; V Jankó; M R Pourshafie; M Katouli; A Brauner Journal: Eur J Clin Microbiol Infect Dis Date: 2011-04-21 Impact factor: 3.267
Authors: Erik W Baars; Eefje Belt-van Zoen; Thomas Breitkreuz; David Martin; Harald Matthes; Tido von Schoen-Angerer; Georg Soldner; Jan Vagedes; Herman van Wietmarschen; Olga Patijn; Merlin Willcox; Paschen von Flotow; Michael Teut; Klaus von Ammon; Madan Thangavelu; Ursula Wolf; Josef Hummelsberger; Ton Nicolai; Philippe Hartemann; Henrik Szőke; Michael McIntyre; Esther T van der Werf; Roman Huber Journal: Evid Based Complement Alternat Med Date: 2019-02-03 Impact factor: 2.629