OBJECTIVE: Preeclampsia has been associated with elevated proinflammatory markers, increased sympathetic activity, and decreased plasma volume (PV). We hypothesized that these associations would be identified in women prior to a first pregnancy. METHODS: We studied 76 healthy nulligravid participants measuring the proinflammatory markers C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-alpha). Plasma volume was measured in supine position and corrected for body mass index (BMI). We examined supine plasma levels of epinephrine and norepinephrine and blood pressure response to Valsalva maneuver to quantify sympathetic activation. We then examined the association of PV and sympathetic activity with proinflammatory cytokines with P < .05 accepted for significance. RESULTS: CRP was significantly increased in participants with lowest PV/BMI quartile when compared to middle 2 quartiles and highest quartile (analysis of variance [ANOVA], P = .037). We found no significant association of PV/BMI with either IL-6 or TNF-alpha. Both plasma epinephrine concentration (r = .29, P = .02) and the late phase II (phase II_L) blood pressure response to Valsalva maneuver (r = .44, P < .0001) were associated with serum IL-6 concentrations. CONCLUSIONS: Low PV is associated with increased CRP levels and increased sympathetic tone is linked to elevated IL-6 concentration in young nonpregnant women. These findings represent elements of a nonpregnancy phenotype that parallels the findings observed in preeclampsia and in women at risk for ischemic cardiovascular disease. This suggests that the relationships observed during preeclampsia, which have been associated with placental pathology, may predate pregnancy and be independent of placental activity.
OBJECTIVE:Preeclampsia has been associated with elevated proinflammatory markers, increased sympathetic activity, and decreased plasma volume (PV). We hypothesized that these associations would be identified in women prior to a first pregnancy. METHODS: We studied 76 healthy nulligravid participants measuring the proinflammatory markers C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-alpha). Plasma volume was measured in supine position and corrected for body mass index (BMI). We examined supine plasma levels of epinephrine and norepinephrine and blood pressure response to Valsalva maneuver to quantify sympathetic activation. We then examined the association of PV and sympathetic activity with proinflammatory cytokines with P < .05 accepted for significance. RESULTS:CRP was significantly increased in participants with lowest PV/BMI quartile when compared to middle 2 quartiles and highest quartile (analysis of variance [ANOVA], P = .037). We found no significant association of PV/BMI with either IL-6 or TNF-alpha. Both plasma epinephrine concentration (r = .29, P = .02) and the late phase II (phase II_L) blood pressure response to Valsalva maneuver (r = .44, P < .0001) were associated with serum IL-6 concentrations. CONCLUSIONS: Low PV is associated with increased CRP levels and increased sympathetic tone is linked to elevated IL-6 concentration in young nonpregnant women. These findings represent elements of a nonpregnancy phenotype that parallels the findings observed in preeclampsia and in women at risk for ischemic cardiovascular disease. This suggests that the relationships observed during preeclampsia, which have been associated with placental pathology, may predate pregnancy and be independent of placental activity.
Authors: M E Spaanderman; R Aardenburg; T H Ekhart; H W van Eyndhoven; O W van der Heijden; J van Eyck; P W de Leeuw; L L Peeters Journal: Eur J Obstet Gynecol Reprod Biol Date: 2001-04 Impact factor: 2.435
Authors: Brenda J Wilson; M Stuart Watson; Gordon J Prescott; Sarah Sunderland; Doris M Campbell; Philip Hannaford; W Cairns S Smith Journal: BMJ Date: 2003-04-19
Authors: Robert Aardenburg; Marc E A Spaanderman; Timo H Ekhart; Hugo W van Eijndhoven; Olivier W H van der Heijden; Louis L H Peeters Journal: BJOG Date: 2003-11 Impact factor: 6.531
Authors: M L Tjoa; J M G van Vugt; A T J J Go; M A Blankenstein; C B M Oudejans; I J van Wijk Journal: J Reprod Immunol Date: 2003-06 Impact factor: 4.054
Authors: Dana P Damron; Beth A Bouchard; Robert E Shapiro; Adrienne L Schonberg; Ira M Bernstein Journal: Obstet Gynecol Date: 2004-05 Impact factor: 7.661
Authors: Carole A McBride; Sarah A Hale; Meenakumari Subramanian; Gary J Badger; Ira M Bernstein Journal: Reprod Sci Date: 2013-09-10 Impact factor: 3.060
Authors: Heberto Suarez-Roca; Rebecca Y Klinger; Mihai V Podgoreanu; Ru-Rong Ji; Martin I Sigurdsson; Nathan Waldron; Joseph P Mathew; William Maixner Journal: Anesthesiology Date: 2019-04 Impact factor: 7.892
Authors: Erin A Morris; Sarah A Hale; Gary J Badger; Ronald R Magness; Ira M Bernstein Journal: Am J Obstet Gynecol Date: 2015-01-07 Impact factor: 8.661
Authors: Sarah Hale; Martha Choate; Adrienne Schonberg; Robert Shapiro; Gary Badger; Ira M Bernstein Journal: Reprod Sci Date: 2010-07-16 Impact factor: 3.060
Authors: Jessica Robinson-Papp; Varuna Astha; Alexandra Nmashie; Sandeep K Sharma; Seunghee Kim-Schulze; Jacinta Murray; Mary Catherine George; Susan Morgello; Bridget R Mueller; Steven A Lawrence; Emma K T Benn Journal: Brain Behav Immun Health Date: 2020-08-03
Authors: J Michael Gaziano; Anthony H Cincotta; Aaron Vinik; Lawrence Blonde; Nancy Bohannon; Richard Scranton Journal: J Am Heart Assoc Date: 2012-10-25 Impact factor: 5.501