Xiaowen Jiang1, Jing Hu. 1. State Key Laboratory of Oral Diseases and the Department of Oral and Maxillofacial Surgery, Sichuan University, Chengdu, China.
Abstract
PURPOSE: To review the literature on drug treatment of oral submucous fibrosis. MATERIALS AND METHODS: An electronic search was performed for articles published from January 1960 to August 2008. RESULTS: Only 17 publications were searched, and 15 publications showed a high level of evidence (6 randomized controlled trials, 4 clinical trials/controlled clinical trials, and 5 other experimental studies), with a total of 1,224 patients. CONCLUSIONS: Few studies with high levels of evidence were found. It is quite difficult to compare or even combine their outcomes in a scientifically meaningful manner. Because of insufficient research data, there is a need for high-quality randomized, controlled trials in this area of medicine.
PURPOSE: To review the literature on drug treatment of oral submucous fibrosis. MATERIALS AND METHODS: An electronic search was performed for articles published from January 1960 to August 2008. RESULTS: Only 17 publications were searched, and 15 publications showed a high level of evidence (6 randomized controlled trials, 4 clinical trials/controlled clinical trials, and 5 other experimental studies), with a total of 1,224 patients. CONCLUSIONS: Few studies with high levels of evidence were found. It is quite difficult to compare or even combine their outcomes in a scientifically meaningful manner. Because of insufficient research data, there is a need for high-quality randomized, controlled trials in this area of medicine.